Heart rate variability during sleep in children with autism spectrum disorder

René Harder, Beth A. Malow, R. Lucas Goodpaster, Fahad Iqbal, Ann Halbower, Suzanne E. Goldman, Diane B. Fawkes, Lily Wang, Yaping Shi, Franz Baudenbacher, André Diedrich

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: Autonomic dysfunction has been reported in autism spectrum disorders (ASD). Less is known about autonomic function during sleep in ASD. The objective of this study is to provide insight into the autonomic cardiovascular control during different sleep stages in ASD. We hypothesized that patients with ASD have lower vagal and higher sympathetic modulation with elevated heart rate, as compared to typical developing children (TD). Methods: We studied 21 children with ASD and 23 TD children during overnight polysomnography. Heart rate and spectral parameters were calculated for each vigilance stage during sleep. Data from the first four sleep cycles were used to avoid possible effects of different individual sleep lengths and sleep cycle structures. Linear regression models were applied to study the effects of age and diagnosis (ASD and TD). Results: In both groups, HR decreased during non-REM sleep and increased during REM sleep. However, HR was significantly higher in stages N2, N3 and REM sleep in the ASD group. Children with ASD showed less high frequency (HF) modulation during N3 and REM sleep. LF/HF ratio was higher during REM. Heart rate decreases with age at the same level in ASD and in TD. We found an age effect in LF in REM different in ASD and TD. Conclusion: Our findings suggest possible deficits in vagal influence to the heart during sleep, especially during REM sleep. Children with ASD may have higher sympathetic dominance during sleep but rather due to decreased vagal influence.

Original languageEnglish (US)
Pages (from-to)423-432
Number of pages10
JournalClinical Autonomic Research
Volume26
Issue number6
DOIs
StatePublished - Dec 1 2016
Externally publishedYes

Fingerprint

Sleep
Heart Rate
REM Sleep
Sleep Stages
Linear Models
Autism Spectrum Disorder
Polysomnography

Keywords

  • Autism
  • Autonomic system
  • Heart rate variability
  • Sleep

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology

Cite this

Harder, R., Malow, B. A., Goodpaster, R. L., Iqbal, F., Halbower, A., Goldman, S. E., ... Diedrich, A. (2016). Heart rate variability during sleep in children with autism spectrum disorder. Clinical Autonomic Research, 26(6), 423-432. https://doi.org/10.1007/s10286-016-0375-5

Heart rate variability during sleep in children with autism spectrum disorder. / Harder, René; Malow, Beth A.; Goodpaster, R. Lucas; Iqbal, Fahad; Halbower, Ann; Goldman, Suzanne E.; Fawkes, Diane B.; Wang, Lily; Shi, Yaping; Baudenbacher, Franz; Diedrich, André.

In: Clinical Autonomic Research, Vol. 26, No. 6, 01.12.2016, p. 423-432.

Research output: Contribution to journalArticle

Harder, R, Malow, BA, Goodpaster, RL, Iqbal, F, Halbower, A, Goldman, SE, Fawkes, DB, Wang, L, Shi, Y, Baudenbacher, F & Diedrich, A 2016, 'Heart rate variability during sleep in children with autism spectrum disorder', Clinical Autonomic Research, vol. 26, no. 6, pp. 423-432. https://doi.org/10.1007/s10286-016-0375-5
Harder R, Malow BA, Goodpaster RL, Iqbal F, Halbower A, Goldman SE et al. Heart rate variability during sleep in children with autism spectrum disorder. Clinical Autonomic Research. 2016 Dec 1;26(6):423-432. https://doi.org/10.1007/s10286-016-0375-5
Harder, René ; Malow, Beth A. ; Goodpaster, R. Lucas ; Iqbal, Fahad ; Halbower, Ann ; Goldman, Suzanne E. ; Fawkes, Diane B. ; Wang, Lily ; Shi, Yaping ; Baudenbacher, Franz ; Diedrich, André. / Heart rate variability during sleep in children with autism spectrum disorder. In: Clinical Autonomic Research. 2016 ; Vol. 26, No. 6. pp. 423-432.
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