Healthy young women with serotonin transporter SS polymorphism show a pro-inflammatory bias under resting and stress conditions

Carolyn A. Fredericks, Emily M. Drabant, Michael D. Edge, Jean M. Tillie, Joachim Hallmayer, Wiveka Ramel, Janice R. Kuo, Sean Mackey, James J. Gross, Firdaus Dhabhar

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The study of functionally relevant biological effects of serotonin transporter gene promoter region (5-HTTLPR) polymorphisms is especially important given the current controversy about the clinical relevance of these polymorphisms. Here we report an intrinsic immunobiological difference between individuals carrying two short (SS) versus long (LL) 5-HTTLPR alleles, that is observed in healthy subjects reporting low exposure to life stress. Given that 5-HTTLPR polymorphisms are thought to influence susceptibility to depression and are associated with robust neurobiological effects, that depression is associated with higher pro-inflammatory and lower anti-inflammatory cytokines, and that acute stressors increase circulating concentrations of pro-inflammatory cytokines, we hypothesized that compared to LL individuals, SS individuals may show a pro-inflammatory bias under resting conditions and/or during stress. 15 LL and 11 SS individuals participated in the Trier Social Stress Test (TSST). Serum IL-6 and IL-10 were quantified at baseline and 30, 60, 90, and 120. min after beginning the 20-min stress test. Compared to LL individuals, SS individuals showed a higher IL-6/IL-10 ratio at baseline and during stress. Importantly, this pro-inflammatory bias was observed despite both groups being healthy, reporting similar intensities of stress and negative emotionality during the TSST, and reporting similar low exposures to early and recent life stress. To our knowledge, this is the first report of a pro-inflammatory bias/phenotype in individuals carrying the SS genotype of 5-HTTLPR. Thus, healthy SS individuals may be chronically exposed to a pro-inflammatory physiological burden under resting and stress conditions, which could increase their vulnerability to disorders like depression and other diseases that can be facilitated/exacerbated by a chronic pro-inflammatory state.

Original languageEnglish (US)
Pages (from-to)350-357
Number of pages8
JournalBrain, Behavior, and Immunity
Volume24
Issue number3
DOIs
StatePublished - Mar 1 2010
Externally publishedYes

Fingerprint

Serotonin Plasma Membrane Transport Proteins
Exercise Test
Depression
Psychological Stress
Interleukin-10
Interleukin-6
Cytokines
Genetic Promoter Regions
Individuality
Healthy Volunteers
Anti-Inflammatory Agents
Alleles
Genotype
Phenotype
Serum
Genes

Keywords

  • 5-HTTLPR
  • Cytokine
  • Depression
  • IL-10
  • IL-6
  • Immunomodulation
  • Inflammation
  • Psychosocial stress
  • Risk factors for depression
  • Serotonin transporter promoter polymorphism

ASJC Scopus subject areas

  • Immunology
  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience

Cite this

Healthy young women with serotonin transporter SS polymorphism show a pro-inflammatory bias under resting and stress conditions. / Fredericks, Carolyn A.; Drabant, Emily M.; Edge, Michael D.; Tillie, Jean M.; Hallmayer, Joachim; Ramel, Wiveka; Kuo, Janice R.; Mackey, Sean; Gross, James J.; Dhabhar, Firdaus.

In: Brain, Behavior, and Immunity, Vol. 24, No. 3, 01.03.2010, p. 350-357.

Research output: Contribution to journalArticle

Fredericks, CA, Drabant, EM, Edge, MD, Tillie, JM, Hallmayer, J, Ramel, W, Kuo, JR, Mackey, S, Gross, JJ & Dhabhar, F 2010, 'Healthy young women with serotonin transporter SS polymorphism show a pro-inflammatory bias under resting and stress conditions', Brain, Behavior, and Immunity, vol. 24, no. 3, pp. 350-357. https://doi.org/10.1016/j.bbi.2009.10.014
Fredericks, Carolyn A. ; Drabant, Emily M. ; Edge, Michael D. ; Tillie, Jean M. ; Hallmayer, Joachim ; Ramel, Wiveka ; Kuo, Janice R. ; Mackey, Sean ; Gross, James J. ; Dhabhar, Firdaus. / Healthy young women with serotonin transporter SS polymorphism show a pro-inflammatory bias under resting and stress conditions. In: Brain, Behavior, and Immunity. 2010 ; Vol. 24, No. 3. pp. 350-357.
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AU - Edge, Michael D.

AU - Tillie, Jean M.

AU - Hallmayer, Joachim

AU - Ramel, Wiveka

AU - Kuo, Janice R.

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