Healing refractory venous ulcers: New treatments offer hope

Robert Kirsner, Katherine L. Baquerizo Nole, Joshua D. Fox, Sophia N. Liu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Non-healing wounds are associated with an inflammatory and proteolytic wound environment, and recent therapeutic strategies have been focused on reversing these changes. Connexins, as members of gap junctions, are important in intercellular signaling and wound repair. Connexin 43 (Cx43) downregulation is associated with normal wound healing, and it has been found to be upregulated in non-healing venous leg ulcers (VLUs). Ghatnekar et al. (2014) report findings of a small phase II trial performed in Indian patients with chronic VLUs, reporting that ACT1, a mimetic peptide of Cx43, accelerates healing in the treatment group. Despite standard care with compression therapy and adjuvant therapy for refractory wounds, at present in clinical practice a significant number of patients remain unhealed. The potential for ACT1 exists to help heal refractory VLUs, but it faces additional regulatory hurdles.

Original languageEnglish (US)
Pages (from-to)19-23
Number of pages5
JournalJournal of Investigative Dermatology
Volume135
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Varicose Ulcer
Connexin 43
Refractory materials
Leg Ulcer
Connexins
Wounds and Injuries
Compaction
Repair
Peptides
Gap Junctions
Therapeutics
Wound Healing
Down-Regulation

ASJC Scopus subject areas

  • Dermatology
  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

Healing refractory venous ulcers : New treatments offer hope. / Kirsner, Robert; Baquerizo Nole, Katherine L.; Fox, Joshua D.; Liu, Sophia N.

In: Journal of Investigative Dermatology, Vol. 135, No. 1, 01.01.2015, p. 19-23.

Research output: Contribution to journalArticle

Kirsner, Robert ; Baquerizo Nole, Katherine L. ; Fox, Joshua D. ; Liu, Sophia N. / Healing refractory venous ulcers : New treatments offer hope. In: Journal of Investigative Dermatology. 2015 ; Vol. 135, No. 1. pp. 19-23.
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