Epatopatia HCV-correlata in emodialisi: manifestazioni biochimiche e cliniche

Translated title of the contribution: HCV-related liver disease in hemodialysis population: clinical and biochemical characteristic

F. Fabrizi, Paul Martin, G. Lunghi, L. Guerra, A. F. De Vecchi, C. Ponticelli

Research output: Contribution to journalArticle

Abstract

Hepatitis C virus (HCV) infection remains frequent among patients on maintenance dialysis. It has been claimed that infrequent and slight abnormalities in serum aminotransferase activity could occur in dialysis patients with HCV. We describe a 61-year-old male patient on maintenance dialysis who acquired HCV by a nosocomial route. The natural history of HCV in this patient over 8 yrs featured frequent and high increases in serum aminotransferase and gamma-glutamyl transpeptidase (gamma-GT) levels. In December 2001, serum GOT and GPT were, respectively, 965 and 1294 UI/L; gamma-GT activity was 241 UI/L. HCV genotype was 2a/2c; median HCV RNA values in serum were 2.3 x 10⁵ UI/mL (range, 1.14 x 10⁴ to 4.6 x 10⁵ UI/mL). Total bilirubin, serum albumin, and colinesterase levels remained normal over the entire follow-up. Liver biopsy was not performed and interferon (IFN) therapy was not given. Currently, biochemical liver tests (GOT/GPT/gamma-GT) are in the upper range of normal values and the patient remains viremic. Efficacy and tolerability of initial monotherapy with IFN for chronic hepatitis C among dialysis patients are briefly discussed. Further studies are warranted to define the optimal anti-viral regimen for chronic hepatitis C in the dialysis population.

Translated title of the contributionHCV-related liver disease in hemodialysis population: clinical and biochemical characteristic
Original languageItalian
Pages (from-to)483-487
Number of pages5
JournalGiornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia
Volume21
Issue number5
StatePublished - Sep 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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