Harnessing neuroendocrine controls of keratin expression: A new therapeutic strategy for skin diseases?

Yuval Ramot, Ralf Paus

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Human skin produces numerous neurohormones and neuropeptides. Recent evidence has shown that the neuroendocrine regulation of human skin biology also extends to keratins, the major structural components of epithelial cells. For example, thyrotropin-releasing hormone, thyrotropin, opioids, prolactin, and cannabinoid receptor 1-ligands profoundly modulate human keratin gene and protein expression in human epidermis and/or hair follicle epithelium in situ. Since selected keratins are now understood to exert important regulatory functions beyond mechanical stability, we argue that neuroendocrine pathways of keratin regulation are important for maintaining skin and hair follicle homeostasis. This invites innovative neuroendocrine therapeutic interventions for skin disorders characterized by abnormal keratin expression, ranging from psoriasis to genodermatoses, and for promoting skin wound healing and hair growth. This strategy can be probed in simple, but instructive and readily available human skin and hair follicle organ culture assays as ideal models for exploring this new neuroendocrine frontier in translational epithelial biology.

Original languageEnglish (US)
Pages (from-to)672-686
Number of pages15
JournalBioEssays
Volume36
Issue number7
DOIs
StatePublished - Jul 2014
Externally publishedYes

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Keywords

  • HPA
  • HPT
  • Prolactin
  • Skin
  • TRH
  • TSH

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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