Haptoglobin quantitation in serum samples from clinically normal and clinically abnormal horses

Carolyn Cray, Rodney L. Belgrave

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Haptoglobin (HP) is a common minor to moderate acute-phase protein in mammals. It has been described as increasing under a variety of conditions in horses, with the use of different assay methods. The goal of the current study was to provide updated information regarding this biomarker by using a commonly available automated assay. In the present study, reference intervals for HP were generated using 43 serum samples from clinically normal horses. The reference interval was determined via the robust method as 0.29-2.26 mg/ml. A statistically significant 3.3-fold mean increase was observed in HP levels from a clinically abnormal group of horses (n=33). A weak but significant correlation was found between total white blood cell count and HP levels (r=0.37, P<.05). A significantly higher level of HP expression was observed in samples acquired from patients whose clinical signs lasted for 7 days or longer than from those whose signs were 4 days or less.

Original languageEnglish (US)
Pages (from-to)337-340
Number of pages4
JournalJournal of Equine Veterinary Science
Volume34
Issue number2
DOIs
StatePublished - Feb 1 2014

Keywords

  • Acute-phase protein
  • Acute-phase response
  • Equine
  • Haptoglobin
  • Inflammation

ASJC Scopus subject areas

  • Equine

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