Haplotype structure and pharmacogenomics

Oliver G. McDonald, William E. Evans

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The inheritance of genetic information in humans (and other diploid organisms) requires that two copies of each chromosome, one paternal and one maternal, be passed on to offspring at conception. This process effectively combines the autosomal genomic DNA sequence from two genetically different parents into their single-diploid progeny. This reproductive strategy continually produces genetic diversity within and among human populations, because the chromosomal DNA sequences of the parents differ from each other and from others in the species or population at various nucleotide positions.

Original languageEnglish (US)
Title of host publicationPharmacogenomics, Second Edition
PublisherCRC Press
Pages441-459
Number of pages19
ISBN (Electronic)9780849359507
ISBN (Print)1574448781, 9781574448788
StatePublished - Jan 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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