Abstract
Hand-held optical imagers are developed by various researchers towards reflectance-based spectroscopic imaging of breast cancer. Recently, a Gen-1 handheld optical imager was developed with capabilities to perform two-dimensional (2-D) spectroscopic as well as three-dimensional (3-D) tomographic imaging studies. However, the imager was bulky with poor surface contact (~30%) along curved tissues, and limited sensitivity to detect targets consistently. Herein, a Gen-2 hand-held optical imager that overcame the above limitations of the Gen-1 imager has been developed and the instrumentation described. The Gen-2 hand-held imager is less bulky, portable, and has improved surface contact (~86%) on curved tissues. Additionally, the forked probe head design is capable of simultaneous bilateral reflectance imaging of both breast tissues, and also transillumination imaging of a single breast tissue. Experimental studies were performed on tissue phantoms to demonstrate the improved sensitivity in detecting targets using the Gen-2 imager. The improved instrumentation of the Gen-2 imager allowed detection of targets independent of their location with respect to the illumination points, unlike in Gen-1 imager. The developed imager has potential for future clinical breast imaging with enhanced sensitivity, via both reflectance and transillumination imaging.
| Original language | English |
|---|---|
| Article number | 081402 |
| Journal | Journal of Biomedical Optics |
| Volume | 17 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2012 |
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Keywords
- Breast imaging
- Diffuse optical imaging
- Hand-held device
- Near-infrared
ASJC Scopus subject areas
- Biomedical Engineering
- Biomaterials
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
Cite this
Hand-held optical imager (Gen-2) : Improved instrumentation and target detectability. / Gonzalez, Jean; DeCerce, Joseph; Erickson, Sarah J.; Martinez, Sergio L.; Nunez, Annie; Roman, Manuela; Traub, Barbara; Flores, Cecilia A.; Roberts, Seigbeh M.; Hernandez, Estrella; Aguirre, Wenceslao; Kiszonas, Richard; Godavarty, Anuradha.
In: Journal of Biomedical Optics, Vol. 17, No. 8, 081402, 01.08.2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hand-held optical imager (Gen-2)
T2 - Improved instrumentation and target detectability
AU - Gonzalez, Jean
AU - DeCerce, Joseph
AU - Erickson, Sarah J.
AU - Martinez, Sergio L.
AU - Nunez, Annie
AU - Roman, Manuela
AU - Traub, Barbara
AU - Flores, Cecilia A.
AU - Roberts, Seigbeh M.
AU - Hernandez, Estrella
AU - Aguirre, Wenceslao
AU - Kiszonas, Richard
AU - Godavarty, Anuradha
PY - 2012/8/1
Y1 - 2012/8/1
N2 - Hand-held optical imagers are developed by various researchers towards reflectance-based spectroscopic imaging of breast cancer. Recently, a Gen-1 handheld optical imager was developed with capabilities to perform two-dimensional (2-D) spectroscopic as well as three-dimensional (3-D) tomographic imaging studies. However, the imager was bulky with poor surface contact (~30%) along curved tissues, and limited sensitivity to detect targets consistently. Herein, a Gen-2 hand-held optical imager that overcame the above limitations of the Gen-1 imager has been developed and the instrumentation described. The Gen-2 hand-held imager is less bulky, portable, and has improved surface contact (~86%) on curved tissues. Additionally, the forked probe head design is capable of simultaneous bilateral reflectance imaging of both breast tissues, and also transillumination imaging of a single breast tissue. Experimental studies were performed on tissue phantoms to demonstrate the improved sensitivity in detecting targets using the Gen-2 imager. The improved instrumentation of the Gen-2 imager allowed detection of targets independent of their location with respect to the illumination points, unlike in Gen-1 imager. The developed imager has potential for future clinical breast imaging with enhanced sensitivity, via both reflectance and transillumination imaging.
AB - Hand-held optical imagers are developed by various researchers towards reflectance-based spectroscopic imaging of breast cancer. Recently, a Gen-1 handheld optical imager was developed with capabilities to perform two-dimensional (2-D) spectroscopic as well as three-dimensional (3-D) tomographic imaging studies. However, the imager was bulky with poor surface contact (~30%) along curved tissues, and limited sensitivity to detect targets consistently. Herein, a Gen-2 hand-held optical imager that overcame the above limitations of the Gen-1 imager has been developed and the instrumentation described. The Gen-2 hand-held imager is less bulky, portable, and has improved surface contact (~86%) on curved tissues. Additionally, the forked probe head design is capable of simultaneous bilateral reflectance imaging of both breast tissues, and also transillumination imaging of a single breast tissue. Experimental studies were performed on tissue phantoms to demonstrate the improved sensitivity in detecting targets using the Gen-2 imager. The improved instrumentation of the Gen-2 imager allowed detection of targets independent of their location with respect to the illumination points, unlike in Gen-1 imager. The developed imager has potential for future clinical breast imaging with enhanced sensitivity, via both reflectance and transillumination imaging.
KW - Breast imaging
KW - Diffuse optical imaging
KW - Hand-held device
KW - Near-infrared
UR - http://www.scopus.com/inward/record.url?scp=84864715852&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864715852&partnerID=8YFLogxK
U2 - 10.1117/1.JBO.17.8.081402
DO - 10.1117/1.JBO.17.8.081402
M3 - Article
C2 - 23224163
AN - SCOPUS:84864715852
VL - 17
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
SN - 1083-3668
IS - 8
M1 - 081402
ER -