Hairy cell leukemia presenting as a peripancreatic mass: Cytomorphology and radiographic correlates

A. P. Subhawong, Ty Subhawong, S. Z. Ali

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Hairy cell leukemia (HCL) usually presents with peripheral cytopenias, diffuse marrow infiltration, and splenomegaly. This chronic lymphoproliferative disorder is not typically associated with lymphadenopathy or mass lesions. We report a case of HCL first treated by splenectomy, followed by several years of interferon therapy. Twenty-five years later, the patient presented with weight loss, fatigue, and a large PET-avid mass surrounding the head of the pancreas. Fine-needle aspiration was pursued to investigate the unusual and infiltrative appearance of the lesion, which was suggestive of another primary malignancy. Cytology smears showed discohesive lymphoid cells with round nuclei and delicate cytoplasmic projections. Flow cytometry confirmed the presence of a clonal B-cell population with bright expression of CD20 as well as CD25 and CD103, diagnostic of HCL. This is the first report of HCL presenting as a peripancreatic mass. The importance of correlation with radiology and clinical history is emphasized when evaluating such lesions.

Original languageEnglish
Pages (from-to)463-466
Number of pages4
JournalActa Cytologica
Volume56
Issue number4
DOIs
StatePublished - Aug 1 2012
Externally publishedYes

Fingerprint

Hairy Cell Leukemia
Lymphoproliferative Disorders
Splenomegaly
Splenectomy
Fine Needle Biopsy
Radiology
Interferons
Fatigue
Cell Biology
Weight Loss
Pancreas
Flow Cytometry
B-Lymphocytes
Bone Marrow
Lymphocytes
Population
Neoplasms
Therapeutics

Keywords

  • Fine-needle aspiration
  • Hairy cell leukemia
  • Peripancreatic mass

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Hairy cell leukemia presenting as a peripancreatic mass : Cytomorphology and radiographic correlates. / Subhawong, A. P.; Subhawong, Ty; Ali, S. Z.

In: Acta Cytologica, Vol. 56, No. 4, 01.08.2012, p. 463-466.

Research output: Contribution to journalArticle

@article{3a077fd0a3ba4b92be5600dc658835b8,
title = "Hairy cell leukemia presenting as a peripancreatic mass: Cytomorphology and radiographic correlates",
abstract = "Hairy cell leukemia (HCL) usually presents with peripheral cytopenias, diffuse marrow infiltration, and splenomegaly. This chronic lymphoproliferative disorder is not typically associated with lymphadenopathy or mass lesions. We report a case of HCL first treated by splenectomy, followed by several years of interferon therapy. Twenty-five years later, the patient presented with weight loss, fatigue, and a large PET-avid mass surrounding the head of the pancreas. Fine-needle aspiration was pursued to investigate the unusual and infiltrative appearance of the lesion, which was suggestive of another primary malignancy. Cytology smears showed discohesive lymphoid cells with round nuclei and delicate cytoplasmic projections. Flow cytometry confirmed the presence of a clonal B-cell population with bright expression of CD20 as well as CD25 and CD103, diagnostic of HCL. This is the first report of HCL presenting as a peripancreatic mass. The importance of correlation with radiology and clinical history is emphasized when evaluating such lesions.",
keywords = "Fine-needle aspiration, Hairy cell leukemia, Peripancreatic mass",
author = "Subhawong, {A. P.} and Ty Subhawong and Ali, {S. Z.}",
year = "2012",
month = "8",
day = "1",
doi = "10.1159/000335731",
language = "English",
volume = "56",
pages = "463--466",
journal = "Acta Cytologica",
issn = "0001-5547",
publisher = "Science Printers and Publishers Inc.",
number = "4",

}

TY - JOUR

T1 - Hairy cell leukemia presenting as a peripancreatic mass

T2 - Cytomorphology and radiographic correlates

AU - Subhawong, A. P.

AU - Subhawong, Ty

AU - Ali, S. Z.

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Hairy cell leukemia (HCL) usually presents with peripheral cytopenias, diffuse marrow infiltration, and splenomegaly. This chronic lymphoproliferative disorder is not typically associated with lymphadenopathy or mass lesions. We report a case of HCL first treated by splenectomy, followed by several years of interferon therapy. Twenty-five years later, the patient presented with weight loss, fatigue, and a large PET-avid mass surrounding the head of the pancreas. Fine-needle aspiration was pursued to investigate the unusual and infiltrative appearance of the lesion, which was suggestive of another primary malignancy. Cytology smears showed discohesive lymphoid cells with round nuclei and delicate cytoplasmic projections. Flow cytometry confirmed the presence of a clonal B-cell population with bright expression of CD20 as well as CD25 and CD103, diagnostic of HCL. This is the first report of HCL presenting as a peripancreatic mass. The importance of correlation with radiology and clinical history is emphasized when evaluating such lesions.

AB - Hairy cell leukemia (HCL) usually presents with peripheral cytopenias, diffuse marrow infiltration, and splenomegaly. This chronic lymphoproliferative disorder is not typically associated with lymphadenopathy or mass lesions. We report a case of HCL first treated by splenectomy, followed by several years of interferon therapy. Twenty-five years later, the patient presented with weight loss, fatigue, and a large PET-avid mass surrounding the head of the pancreas. Fine-needle aspiration was pursued to investigate the unusual and infiltrative appearance of the lesion, which was suggestive of another primary malignancy. Cytology smears showed discohesive lymphoid cells with round nuclei and delicate cytoplasmic projections. Flow cytometry confirmed the presence of a clonal B-cell population with bright expression of CD20 as well as CD25 and CD103, diagnostic of HCL. This is the first report of HCL presenting as a peripancreatic mass. The importance of correlation with radiology and clinical history is emphasized when evaluating such lesions.

KW - Fine-needle aspiration

KW - Hairy cell leukemia

KW - Peripancreatic mass

UR - http://www.scopus.com/inward/record.url?scp=84864202618&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864202618&partnerID=8YFLogxK

U2 - 10.1159/000335731

DO - 10.1159/000335731

M3 - Article

C2 - 22846478

AN - SCOPUS:84864202618

VL - 56

SP - 463

EP - 466

JO - Acta Cytologica

JF - Acta Cytologica

SN - 0001-5547

IS - 4

ER -