Hair loss in autoimmune cutaneous bullous disorders

The expression of the basement membrane zone (BMZ) components in the anagen hair follicles of the human scalp is similar to that of interfollicular epidermis. Expression of the BMZ components varies according to the different follicular portions. Blistering of the scalp, involving lamina lucida and below, usually leads to scarring alopecia secondary to the inflammatory process in the interfollicular epidermis and in the upper portion of the hair follicle. This article discusses the presence of alopecia in the most common acquired forms of bullous disorders.