Hair growth control by innate immunocytes: Perifollicular macrophages revisited

Ferhan Muneeb, Jonathan A. Hardman, Ralf Paus

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The role of innate immunocytes such as mast cells, γδ T cells, NK cells and macrophages (MACs) in hair growth control under physiological and pathological conditions has recently begun to be re-explored. Here, we revisit the role of resident perifollicular macrophages (pfMACs) located in the hair follicle (HF) mesenchyme (CTS). Substantial, stringently timed fluctuations in the number and localization of pfMACs were first observed long ago during murine HF morphogenesis and cycling. This already suggested some involvement of these innate immunocytes, with a recognized role in tissue remodelling and in hair growth control. The relatively recent demonstration of a Wnt signalling-driven crosstalk between these immunocytes and HF epithelial stem cells in telogen HFs, which promotes anagen induction, has reinvigorated interest in the role that pfMAC plays in hair biology. Besides the apoptosis-associated secretion of stem cell–activating Wnts and the differential secretion of HF-targeting growth factors such as FGF-5 and FGF5s from pfMACs, we also explore how MAC polarization, and thus function, may be influenced by the local metabolic and immune environment. Moreover, we examine how pfMACs may contribute to hair cycle–associated angiogenesis, vascular remodelling, HF immune privilege and immunopathology. On this basis, we discuss why targeting pfMACs may be relevant in the management of hair growth disorders. Finally, we argue that studying pfMACs offers an excellent, clinically relevant model system for characterizing and experimentally manipulating MAC interactions with an easily accessible mammalian, continuously remodelled (mini-)organ under both physiological and pathological conditions.

Original languageEnglish (US)
Pages (from-to)425-431
Number of pages7
JournalExperimental dermatology
Volume28
Issue number4
DOIs
StatePublished - Apr 1 2019

Fingerprint

Macrophages
Hair Follicle
Growth
Growth Disorders
T-cells
Mesoderm
Crosstalk
Stem cells
Morphogenesis
Mast Cells
Natural Killer Cells
Intercellular Signaling Peptides and Proteins
Demonstrations
Stem Cells
Epithelial Cells
Polarization
Tissue
Apoptosis
T-Lymphocytes

Keywords

  • hair cycle
  • hair follicle
  • immunology
  • macrophages
  • skin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

Cite this

Hair growth control by innate immunocytes : Perifollicular macrophages revisited. / Muneeb, Ferhan; Hardman, Jonathan A.; Paus, Ralf.

In: Experimental dermatology, Vol. 28, No. 4, 01.04.2019, p. 425-431.

Research output: Contribution to journalArticle

Muneeb, Ferhan ; Hardman, Jonathan A. ; Paus, Ralf. / Hair growth control by innate immunocytes : Perifollicular macrophages revisited. In: Experimental dermatology. 2019 ; Vol. 28, No. 4. pp. 425-431.
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