Abstract
The discovery of epithelial stem cells (eSCs) in the bulge region of the outer root sheath of hair follicles in mice and man has encouraged research into utilizing the hair follicle as a therapeutic source of stem cells (SCs) for regenerative medicine, and has called attention to the hair follicle as a highly instructive model system for SC biology. Under physiological circumstances, bulge eSCs serve as cell pool for the cyclic regeneration of the anagen hair bulb, while they can also regenerate the sebaceous gland and the epidermis after injury. More recently, melanocyte SCs, nestin+, mesenchymal and additional, as yet ill-defined "stem cell" populations, have also been identified in or immediately adjacent to the hair follicle epithelium, including in the specialized hair follicle mesenchyme (connective tissue sheath), which is crucial to wound healing. Thus the hair follicle and its adjacent tissue environment contain unipotent, multipotent, and possibly even pluripotent SC populations of different developmental origin. It provides an ideal model system for the study of central issues in SC biology such as plasticity and SC niches, and for the identification of reliable, specific SC markers, which distinguish them from their immediate progeny (e.g. transient amplifying cells). The current review attempts to provide some guidance in this growing maze of hair follicle-associated SCs and their progeny, critically reviews potential or claimed hair follicle SC markers, highlights related differences between murine and human hair follicles, and defines major unanswered questions in this rapidly advancing field.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 355-376 |
| Number of pages | 22 |
| Journal | European Journal of Cell Biology |
| Volume | 86 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 27 2007 |
| Externally published | Yes |
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Keywords
- Epidermal neural crest SC
- Epithelial SC
- Hair follicle
- Label-retaining cells
- Melanocyte SC
- Mesenchymal SC
- Skin-derived precursors
- Stem cell (SC)
ASJC Scopus subject areas
- Anatomy
- Cell Biology
Cite this
Hair follicle stem cells : Walking the maze. / Tiede, Stephan; Kloepper, Jennifer E.; Bodò, Enikö; Tiwari, Sanjay; Kruse, Charli; Paus, Ralf.
In: European Journal of Cell Biology, Vol. 86, No. 7, 27.07.2007, p. 355-376.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hair follicle stem cells
T2 - Walking the maze
AU - Tiede, Stephan
AU - Kloepper, Jennifer E.
AU - Bodò, Enikö
AU - Tiwari, Sanjay
AU - Kruse, Charli
AU - Paus, Ralf
PY - 2007/7/27
Y1 - 2007/7/27
N2 - The discovery of epithelial stem cells (eSCs) in the bulge region of the outer root sheath of hair follicles in mice and man has encouraged research into utilizing the hair follicle as a therapeutic source of stem cells (SCs) for regenerative medicine, and has called attention to the hair follicle as a highly instructive model system for SC biology. Under physiological circumstances, bulge eSCs serve as cell pool for the cyclic regeneration of the anagen hair bulb, while they can also regenerate the sebaceous gland and the epidermis after injury. More recently, melanocyte SCs, nestin+, mesenchymal and additional, as yet ill-defined "stem cell" populations, have also been identified in or immediately adjacent to the hair follicle epithelium, including in the specialized hair follicle mesenchyme (connective tissue sheath), which is crucial to wound healing. Thus the hair follicle and its adjacent tissue environment contain unipotent, multipotent, and possibly even pluripotent SC populations of different developmental origin. It provides an ideal model system for the study of central issues in SC biology such as plasticity and SC niches, and for the identification of reliable, specific SC markers, which distinguish them from their immediate progeny (e.g. transient amplifying cells). The current review attempts to provide some guidance in this growing maze of hair follicle-associated SCs and their progeny, critically reviews potential or claimed hair follicle SC markers, highlights related differences between murine and human hair follicles, and defines major unanswered questions in this rapidly advancing field.
AB - The discovery of epithelial stem cells (eSCs) in the bulge region of the outer root sheath of hair follicles in mice and man has encouraged research into utilizing the hair follicle as a therapeutic source of stem cells (SCs) for regenerative medicine, and has called attention to the hair follicle as a highly instructive model system for SC biology. Under physiological circumstances, bulge eSCs serve as cell pool for the cyclic regeneration of the anagen hair bulb, while they can also regenerate the sebaceous gland and the epidermis after injury. More recently, melanocyte SCs, nestin+, mesenchymal and additional, as yet ill-defined "stem cell" populations, have also been identified in or immediately adjacent to the hair follicle epithelium, including in the specialized hair follicle mesenchyme (connective tissue sheath), which is crucial to wound healing. Thus the hair follicle and its adjacent tissue environment contain unipotent, multipotent, and possibly even pluripotent SC populations of different developmental origin. It provides an ideal model system for the study of central issues in SC biology such as plasticity and SC niches, and for the identification of reliable, specific SC markers, which distinguish them from their immediate progeny (e.g. transient amplifying cells). The current review attempts to provide some guidance in this growing maze of hair follicle-associated SCs and their progeny, critically reviews potential or claimed hair follicle SC markers, highlights related differences between murine and human hair follicles, and defines major unanswered questions in this rapidly advancing field.
KW - Epidermal neural crest SC
KW - Epithelial SC
KW - Hair follicle
KW - Label-retaining cells
KW - Melanocyte SC
KW - Mesenchymal SC
KW - Skin-derived precursors
KW - Stem cell (SC)
UR - http://www.scopus.com/inward/record.url?scp=34250844983&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34250844983&partnerID=8YFLogxK
U2 - 10.1016/j.ejcb.2007.03.006
DO - 10.1016/j.ejcb.2007.03.006
M3 - Article
C2 - 17576022
AN - SCOPUS:34250844983
VL - 86
SP - 355
EP - 376
JO - European Journal of Cell Biology
JF - European Journal of Cell Biology
SN - 0171-9335
IS - 7
ER -