Hair follicle pigmentation

Andrzej Slominski, Jacobo Wortsman, Przemyslaw M. Plonka, Karin U. Schallreuter, Ralf Paus, Desmond J. Tobin

Research output: Contribution to journalReview article

298 Citations (Scopus)

Abstract

Hair shaft melanin components (eu- or/and pheomelanin) are a long-lived record of precise interactions in the hair follicle pigmentary unit, e.g., between follicular melanocytes, keratinocytes, and dermal papilla fibroblasts. Follicular melanogenesis (FM) involves sequentially the melanogenic activity of follicular melanocytes, the transfer of melanin granules into cortical and medulla keratinocytes, and the formation of pigmented hair shafts. This activity is in turn regulated by an array of enzymes, structural and regulatory proteins, transporters, and receptors and their ligands, acting on the developmental stages, cellular, and hair follicle levels. FM is stringently coupled to the anagen stage of the hair cycle, being switched-off in catagen to remain absent through telogen. At the organ level FM is precisely coupled to the life cycle of melanocytes with changes in their compartmental distribution and accelerated melanoblast/melanocyte differentiation with enhanced secretory activity. The melanocyte compartments in the upper hair follicle also provides a reservoir for the repigmentation of epidermis and, for the cyclic formation of new anagen hair bulbs. Melanin synthesis and pigment transfer to bulb keratinocytes are dependent on the availability of melanin precursors, and regulation by signal transduction pathways intrinsic to skin and hair follicle, which are both receptor dependent and independent, act through auto-, para- or intracrine mechanisms and can be modified by hormonal signals. The important regulators are MC1 receptor its and adrenocorticotropic hormone, melanocyte stimulating hormone, agouti protein ligands (in rodents), c-Kit, and the endothelin receptors with their ligands. Melanin itself has a wide range of bioactivities that extend far beyond its determination of hair color.

Original languageEnglish (US)
Pages (from-to)13-21
Number of pages9
JournalJournal of Investigative Dermatology
Volume124
Issue number1
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

Fingerprint

Hair Follicle
Melanocytes
Melanins
Pigmentation
Hair
Keratinocytes
Ligands
Agouti Signaling Protein
Receptor, Melanocortin, Type 1
Melanocyte-Stimulating Hormones
Endothelin Receptors
Signal transduction
Hair Color
Proto-Oncogene Proteins c-kit
Fibroblasts
Bioactivity
Skin
Pigments
Adrenocorticotropic Hormone
Life cycle

Keywords

  • Follicular melanocytes
  • Hair pigmentation
  • Melanin
  • Melanogenesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Slominski, A., Wortsman, J., Plonka, P. M., Schallreuter, K. U., Paus, R., & Tobin, D. J. (2005). Hair follicle pigmentation. Journal of Investigative Dermatology, 124(1), 13-21. https://doi.org/10.1111/j.0022-202X.2004.23528.x

Hair follicle pigmentation. / Slominski, Andrzej; Wortsman, Jacobo; Plonka, Przemyslaw M.; Schallreuter, Karin U.; Paus, Ralf; Tobin, Desmond J.

In: Journal of Investigative Dermatology, Vol. 124, No. 1, 01.01.2005, p. 13-21.

Research output: Contribution to journalReview article

Slominski, A, Wortsman, J, Plonka, PM, Schallreuter, KU, Paus, R & Tobin, DJ 2005, 'Hair follicle pigmentation', Journal of Investigative Dermatology, vol. 124, no. 1, pp. 13-21. https://doi.org/10.1111/j.0022-202X.2004.23528.x
Slominski A, Wortsman J, Plonka PM, Schallreuter KU, Paus R, Tobin DJ. Hair follicle pigmentation. Journal of Investigative Dermatology. 2005 Jan 1;124(1):13-21. https://doi.org/10.1111/j.0022-202X.2004.23528.x
Slominski, Andrzej ; Wortsman, Jacobo ; Plonka, Przemyslaw M. ; Schallreuter, Karin U. ; Paus, Ralf ; Tobin, Desmond J. / Hair follicle pigmentation. In: Journal of Investigative Dermatology. 2005 ; Vol. 124, No. 1. pp. 13-21.
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