Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management

Ralf Paus, Silvia Bulfone-Paus, Marta Bertolini

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

The collapse of the immune privilege (IP) of the anagen hair bulb is now accepted as a key element in AA pathogenesis, and hair bulb IP restoration lies at the core of AA therapy. Here, we briefly review the essentials of hair bulb IP and recent progress in understanding its complexity. We discuss open questions and why the systematic dissection of hair bulb IP and its pharmacological manipulation (including the clinical testing of FK506 and α-melanocyte-stimulating hormone analogs) promise to extend the range of future therapeutic options in AA and other IP collapse-related autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)S12-S17
JournalJournal of Investigative Dermatology Symposium Proceedings
Volume19
Issue number1
DOIs
StatePublished - Jan 2018
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Dermatology
  • Cell Biology

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