Haemostatic abnormalities in systemic lupus erythematosus

D. D. Gladman, M. B. Urowitz, Elaine Tozman, M. F X Glynn

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33 Scopus citations

Abstract

Coagulation studies were performed in 112 consecutive patients with systemic lupus erythematosus (SLE). Abnormalities of haemostatic function occurred frequently and 96 abnormalities occurred in 64 of 112 (57%) patients. Eighteen patients (16%) had thrombocytopenia, 19 (16.9%) had circulating anticoagulants and 24 had decreased antithrombin III levels. Abnormalities of fibrinogen were found in 28 patients (23%), and abnormalities of platelet factor 3 and 4, indicating in vivo platelet activation occurred in 7 patients. In 25 patients 2 or more abnormalities were detected simultaneously. No haemostatic abnormalities were detected in any of the 50 healthy volunteers who served as controls. Only 1 patient with thrombocytopenia had petechiae. None of the other patients, even those with multiple defects bled significantly, but several patients had vasculitis and/or phlebitis. There was no correlation between disease activity of SLE and the presence of haemostatic abnormalities, nor was there an association between these abnormalities and specific clinical haemotologic manifestations.

Original languageEnglish
Title of host publicationQuarterly Journal of Medicine
Pages424-433
Number of pages10
Volume52
Edition207
StatePublished - Dec 1 1983
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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Gladman, D. D., Urowitz, M. B., Tozman, E., & Glynn, M. F. X. (1983). Haemostatic abnormalities in systemic lupus erythematosus. In Quarterly Journal of Medicine (207 ed., Vol. 52, pp. 424-433)