Coagulation studies were performed in 112 consecutive patients with systemic lupus erythematosus (SLE). Abnormalities of haemostatic function occurred frequently and 96 abnormalities occurred in 64 of 112 (57%) patients. Eighteen patients (16%) had thrombocytopenia, 19 (16.9%) had circulating anticoagulants and 24 had decreased antithrombin III levels. Abnormalities of fibrinogen were found in 28 patients (23%), and abnormalities of platelet factor 3 and 4, indicating in vivo platelet activation occurred in 7 patients. In 25 patients 2 or more abnormalities were detected simultaneously. No haemostatic abnormalities were detected in any of the 50 healthy volunteers who served as controls. Only 1 patient with thrombocytopenia had petechiae. None of the other patients, even those with multiple defects bled significantly, but several patients had vasculitis and/or phlebitis. There was no correlation between disease activity of SLE and the presence of haemostatic abnormalities, nor was there an association between these abnormalities and specific clinical haemotologic manifestations.
|Title of host publication||Quarterly Journal of Medicine|
|Number of pages||10|
|State||Published - Dec 1 1983|
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