Habituation of rostral anterior cingulate cortex to repeated emotionally salient pictures

K. Luan Phan, Israel Liberzon, Robert C. Welsh, Jennifer C Britton, Stephan F. Taylor

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Habituation of the neural response to repeated stimuli has been well demonstrated for subcortical limbic regions responding to emotionally salient stimuli. Although the rostral or affective division of the anterior cingulate cortex (rACC) is also engaged during emotional processing, little is known about the temporal dynamics of this region in sustained evaluation of emotional salience. Using a test/retest design, the present study assessed habituation in the human brain with functional magnetic resonance imaging. Eight healthy subjects were exposed to two repeated runs of aversive, neutral, and blank images. Activation of the rACC to negatively valenced pictures occurred only in the first session, and this activation was significantly greater in the first relative to the second session. Additionally, medial prefrontal cortex, hippocampal, and amygdalar activations were noted during the first, but not second, presentation of aversive pictures. These findings highlight the phasic activity of the rACC in emotional processing consistent with habituation.

Original languageEnglish
Pages (from-to)1344-1350
Number of pages7
JournalNeuropsychopharmacology
Volume28
Issue number7
DOIs
StatePublished - Jul 1 2003
Externally publishedYes

Fingerprint

Gyrus Cinguli
Temporal Lobe
Prefrontal Cortex
Healthy Volunteers
Magnetic Resonance Imaging
Brain

Keywords

  • Attention
  • Emotion
  • Functional magnetic resonance imaging
  • Habituation
  • Pictures
  • Prefrontal cortex

ASJC Scopus subject areas

  • Pharmacology

Cite this

Habituation of rostral anterior cingulate cortex to repeated emotionally salient pictures. / Phan, K. Luan; Liberzon, Israel; Welsh, Robert C.; Britton, Jennifer C; Taylor, Stephan F.

In: Neuropsychopharmacology, Vol. 28, No. 7, 01.07.2003, p. 1344-1350.

Research output: Contribution to journalArticle

Phan, K. Luan ; Liberzon, Israel ; Welsh, Robert C. ; Britton, Jennifer C ; Taylor, Stephan F. / Habituation of rostral anterior cingulate cortex to repeated emotionally salient pictures. In: Neuropsychopharmacology. 2003 ; Vol. 28, No. 7. pp. 1344-1350.
@article{b997f42448314f26b2fcd418ecd920b3,
title = "Habituation of rostral anterior cingulate cortex to repeated emotionally salient pictures",
abstract = "Habituation of the neural response to repeated stimuli has been well demonstrated for subcortical limbic regions responding to emotionally salient stimuli. Although the rostral or affective division of the anterior cingulate cortex (rACC) is also engaged during emotional processing, little is known about the temporal dynamics of this region in sustained evaluation of emotional salience. Using a test/retest design, the present study assessed habituation in the human brain with functional magnetic resonance imaging. Eight healthy subjects were exposed to two repeated runs of aversive, neutral, and blank images. Activation of the rACC to negatively valenced pictures occurred only in the first session, and this activation was significantly greater in the first relative to the second session. Additionally, medial prefrontal cortex, hippocampal, and amygdalar activations were noted during the first, but not second, presentation of aversive pictures. These findings highlight the phasic activity of the rACC in emotional processing consistent with habituation.",
keywords = "Attention, Emotion, Functional magnetic resonance imaging, Habituation, Pictures, Prefrontal cortex",
author = "Phan, {K. Luan} and Israel Liberzon and Welsh, {Robert C.} and Britton, {Jennifer C} and Taylor, {Stephan F.}",
year = "2003",
month = "7",
day = "1",
doi = "10.1038/sj.npp.1300186",
language = "English",
volume = "28",
pages = "1344--1350",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Nature Publishing Group",
number = "7",

}

TY - JOUR

T1 - Habituation of rostral anterior cingulate cortex to repeated emotionally salient pictures

AU - Phan, K. Luan

AU - Liberzon, Israel

AU - Welsh, Robert C.

AU - Britton, Jennifer C

AU - Taylor, Stephan F.

PY - 2003/7/1

Y1 - 2003/7/1

N2 - Habituation of the neural response to repeated stimuli has been well demonstrated for subcortical limbic regions responding to emotionally salient stimuli. Although the rostral or affective division of the anterior cingulate cortex (rACC) is also engaged during emotional processing, little is known about the temporal dynamics of this region in sustained evaluation of emotional salience. Using a test/retest design, the present study assessed habituation in the human brain with functional magnetic resonance imaging. Eight healthy subjects were exposed to two repeated runs of aversive, neutral, and blank images. Activation of the rACC to negatively valenced pictures occurred only in the first session, and this activation was significantly greater in the first relative to the second session. Additionally, medial prefrontal cortex, hippocampal, and amygdalar activations were noted during the first, but not second, presentation of aversive pictures. These findings highlight the phasic activity of the rACC in emotional processing consistent with habituation.

AB - Habituation of the neural response to repeated stimuli has been well demonstrated for subcortical limbic regions responding to emotionally salient stimuli. Although the rostral or affective division of the anterior cingulate cortex (rACC) is also engaged during emotional processing, little is known about the temporal dynamics of this region in sustained evaluation of emotional salience. Using a test/retest design, the present study assessed habituation in the human brain with functional magnetic resonance imaging. Eight healthy subjects were exposed to two repeated runs of aversive, neutral, and blank images. Activation of the rACC to negatively valenced pictures occurred only in the first session, and this activation was significantly greater in the first relative to the second session. Additionally, medial prefrontal cortex, hippocampal, and amygdalar activations were noted during the first, but not second, presentation of aversive pictures. These findings highlight the phasic activity of the rACC in emotional processing consistent with habituation.

KW - Attention

KW - Emotion

KW - Functional magnetic resonance imaging

KW - Habituation

KW - Pictures

KW - Prefrontal cortex

UR - http://www.scopus.com/inward/record.url?scp=0042423407&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042423407&partnerID=8YFLogxK

U2 - 10.1038/sj.npp.1300186

DO - 10.1038/sj.npp.1300186

M3 - Article

C2 - 12784119

AN - SCOPUS:0042423407

VL - 28

SP - 1344

EP - 1350

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

IS - 7

ER -