HAART to Heart

Highly active antiretroviral therapy and the risk of cardiovascular disease in HIV-infected or exposed children and adults

Steven E Lipshultz, Catherine M. Mas, Jacqueline M. Henkel, Vivian I. Franco, Stacy D. Fisher, Tracie L Miller

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Infection with HIV is independently associated with an increased risk for clinical heart failure, cardiomyopathies and premature atherosclerosis, including stroke and myocardial infarction in both the pre-HAART and HAART eras. HAART is also associated with clinical cardiovascular concerns. In HIV-infected individuals, HAART may cause adverse lipid profiles and increased risk for cardiovascular events. Its effects on the developing heart remain unclear. Although in utero HAART exposure may improve cardiac function in the first 2 years of life, it may also inhibit myocardial growth. Additional potentially damaging cardiovascular effects of HAART are present, and continuing cardiovascular risk evaluations, screening and follow-up of treated patients is necessary. Here, we review available research in this field and highlight the importance of understanding known complications and their mechanisms.

Original languageEnglish
Pages (from-to)661-674
Number of pages14
JournalExpert Review of Anti-Infective Therapy
Volume10
Issue number6
DOIs
StatePublished - Jun 1 2012

Fingerprint

Highly Active Antiretroviral Therapy
Cardiovascular Diseases
HIV
Cardiomyopathies
HIV Infections
Atherosclerosis
Heart Failure
Stroke
Myocardial Infarction
Lipids
Growth
Research

Keywords

  • AIDS
  • antiretroviral therapy
  • cardiovascular disease
  • heart
  • HIV
  • vasculature

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology
  • Virology

Cite this

HAART to Heart : Highly active antiretroviral therapy and the risk of cardiovascular disease in HIV-infected or exposed children and adults. / Lipshultz, Steven E; Mas, Catherine M.; Henkel, Jacqueline M.; Franco, Vivian I.; Fisher, Stacy D.; Miller, Tracie L.

In: Expert Review of Anti-Infective Therapy, Vol. 10, No. 6, 01.06.2012, p. 661-674.

Research output: Contribution to journalArticle

Lipshultz, Steven E ; Mas, Catherine M. ; Henkel, Jacqueline M. ; Franco, Vivian I. ; Fisher, Stacy D. ; Miller, Tracie L. / HAART to Heart : Highly active antiretroviral therapy and the risk of cardiovascular disease in HIV-infected or exposed children and adults. In: Expert Review of Anti-Infective Therapy. 2012 ; Vol. 10, No. 6. pp. 661-674.
@article{527755e75ad34604ad7cf1aeb0df6216,
title = "HAART to Heart: Highly active antiretroviral therapy and the risk of cardiovascular disease in HIV-infected or exposed children and adults",
abstract = "Infection with HIV is independently associated with an increased risk for clinical heart failure, cardiomyopathies and premature atherosclerosis, including stroke and myocardial infarction in both the pre-HAART and HAART eras. HAART is also associated with clinical cardiovascular concerns. In HIV-infected individuals, HAART may cause adverse lipid profiles and increased risk for cardiovascular events. Its effects on the developing heart remain unclear. Although in utero HAART exposure may improve cardiac function in the first 2 years of life, it may also inhibit myocardial growth. Additional potentially damaging cardiovascular effects of HAART are present, and continuing cardiovascular risk evaluations, screening and follow-up of treated patients is necessary. Here, we review available research in this field and highlight the importance of understanding known complications and their mechanisms.",
keywords = "AIDS, antiretroviral therapy, cardiovascular disease, heart, HIV, vasculature",
author = "Lipshultz, {Steven E} and Mas, {Catherine M.} and Henkel, {Jacqueline M.} and Franco, {Vivian I.} and Fisher, {Stacy D.} and Miller, {Tracie L}",
year = "2012",
month = "6",
day = "1",
doi = "10.1586/eri.12.53",
language = "English",
volume = "10",
pages = "661--674",
journal = "Expert Review of Anti-Infective Therapy",
issn = "1478-7210",
publisher = "Expert Reviews Ltd.",
number = "6",

}

TY - JOUR

T1 - HAART to Heart

T2 - Highly active antiretroviral therapy and the risk of cardiovascular disease in HIV-infected or exposed children and adults

AU - Lipshultz, Steven E

AU - Mas, Catherine M.

AU - Henkel, Jacqueline M.

AU - Franco, Vivian I.

AU - Fisher, Stacy D.

AU - Miller, Tracie L

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Infection with HIV is independently associated with an increased risk for clinical heart failure, cardiomyopathies and premature atherosclerosis, including stroke and myocardial infarction in both the pre-HAART and HAART eras. HAART is also associated with clinical cardiovascular concerns. In HIV-infected individuals, HAART may cause adverse lipid profiles and increased risk for cardiovascular events. Its effects on the developing heart remain unclear. Although in utero HAART exposure may improve cardiac function in the first 2 years of life, it may also inhibit myocardial growth. Additional potentially damaging cardiovascular effects of HAART are present, and continuing cardiovascular risk evaluations, screening and follow-up of treated patients is necessary. Here, we review available research in this field and highlight the importance of understanding known complications and their mechanisms.

AB - Infection with HIV is independently associated with an increased risk for clinical heart failure, cardiomyopathies and premature atherosclerosis, including stroke and myocardial infarction in both the pre-HAART and HAART eras. HAART is also associated with clinical cardiovascular concerns. In HIV-infected individuals, HAART may cause adverse lipid profiles and increased risk for cardiovascular events. Its effects on the developing heart remain unclear. Although in utero HAART exposure may improve cardiac function in the first 2 years of life, it may also inhibit myocardial growth. Additional potentially damaging cardiovascular effects of HAART are present, and continuing cardiovascular risk evaluations, screening and follow-up of treated patients is necessary. Here, we review available research in this field and highlight the importance of understanding known complications and their mechanisms.

KW - AIDS

KW - antiretroviral therapy

KW - cardiovascular disease

KW - heart

KW - HIV

KW - vasculature

UR - http://www.scopus.com/inward/record.url?scp=84863204919&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863204919&partnerID=8YFLogxK

U2 - 10.1586/eri.12.53

DO - 10.1586/eri.12.53

M3 - Article

VL - 10

SP - 661

EP - 674

JO - Expert Review of Anti-Infective Therapy

JF - Expert Review of Anti-Infective Therapy

SN - 1478-7210

IS - 6

ER -