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H.2 Cytotoxic responses of damselfish toward dnf tumors. / McKinney, E. C.; Schmale, M. C.In: Developmental and Comparative Immunology, Vol. 18, No. SUPPL. 1, 1994, p. S133.
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TY - JOUR
T1 - H.2 Cytotoxic responses of damselfish toward dnf tumors
AU - McKinney, E. C.
AU - Schmale, M. C.
N1 - Funding Information: Luke Qi Jiang', Martin F. Flajnik 2, E. Churchill McKinney 2, J. Wayne Streilein' tSchepens Eye Research Institute and Dept. of Ophthalmology, Harvard Medical School, Boston, MA, USA, and ~University of Miami, Dept. Microbiology and Immunology, Miami, FL, USA The mammalian eye, a part of the central nervous system (CNS), is known as an immunologically privileged site in which foreign tissue grafts enjoy prolonged survival. This privilege is associated with an active down-regulation of systemic immune responses. It is also known that the capacity of neural regeneration in the CNS is lacking in higher vertebrates but exists in lower vertebrates. The purpose of our study was to determine whether immune privilege exists in lower vertebrates and to explore from an evolutionary point of view the relationship between immune privilege and neural regeneration. Experiments were conducted in three species: goldfish, frog and mouse. Neural retinal allografts and autografts (or syngeneic grafts) were implanted into the vitreous of the eyes and the fate of the grafts was determined. In order to detect whether the donor-specific immune suppression was induced subsequent allografts (scales of fish or skin of frog) from the same donor were implanted and evaluated for survival. In mice, the delayed hypersensitivity (DH) was measured after donor-specific ear challenge. Our results demonstrate that foreign tissue grafts in either goldfish or frog eyes were rapidly rejected within eight days. There was no evidence of down-regulation of immune responses as shown by rapid rejection of scale or skin grafts. In contrast, retinal allografts in the mouse eye survived very well through at least 17 days and the retinal graft induced suppression of donor-specific DH in its recipient. Absence of immune privilege in goldfish and frog eye and its existence in the mouse eye implies that immune privilege in the CNS may be an evolutionary adaptation acquired by higher vertebrates. Therefore, immune privilege and neural regeneration may be mutually exclusive properties expressed during evolution. Supported by USPHS Grant EY-09595 (LQJ) and a grant from the National Retinitis Pigmentosa Foundation (LQJ).
PY - 1994
Y1 - 1994
UR - http://www.scopus.com/inward/record.url?scp=27244462011&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27244462011&partnerID=8YFLogxK
U2 - 10.1016/0145-305X(94)90190-2
DO - 10.1016/0145-305X(94)90190-2
M3 - Article
AN - SCOPUS:27244462011
VL - 18
SP - S133
JO - Developmental and Comparative Immunology
JF - Developmental and Comparative Immunology
SN - 0145-305X
IS - SUPPL. 1