Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques

Ivan Vujkovic-Cvijin, Louise A. Swainson, Simon N. Chu, Alexandra M. Ortiz, Clark A. Santee, Annalise Petriello, Richard M. Dunham, Douglas W. Fadrosh, Din L. Lin, Ali A. Faruqi, Yong Huang, Cristian Apetrei, Ivona Pandrea, Frederick M. Hecht, Christopher D. Pilcher, Nichole Klatt, Jason M. Brenchley, Susan V. Lynch, Joseph M. McCune

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Gut microbes can profoundly modulate mucosal barrier-promoting Th17 cells in mammals. A salient feature of HIV/simian immunodeficiency virus (SIV) immunopathogenesis is the loss of Th17 cells, which has been linked to increased activity of the immunomodulatory enzyme, indoleamine 2,3-dioxygenase 1 (IDO 1). The role of gut microbes in this system remains unknown, and the SIV-infected rhesus macaque provides a well-described model for HIV-associated Th17 loss and mucosal immune disruption. We observed a specific depletion of gut-resident Lactobacillus during acute and chronic SIV infection of rhesus macaques, which was also seen in early HIV-infected humans. This depletion in rhesus macaques correlated with increased IDO1 activity and Th17 loss. Macaques supplemented with a Lactobacillus-containing probiotic exhibited decreased IDO1 activity during chronic SIV infection. We propose that Lactobacillus species inhibit mammalian IDO1 and thus may help to preserve Th17 cells during pathogenic SIV infection, providing support for Lactobacillus species as modulators of mucosal immune homeostasis. Vujkovic-Cvijin et al. show that fecal Lactobacillus associates with control of the immunomodulatory indoleamine 2,3-dioxygenase (IDO) pathway, providing a link between the gut microbiome and mucosal immune homeostasis in the pathogenesis of SIV disease.

Original languageEnglish (US)
Pages (from-to)1589-1597
Number of pages9
JournalCell Reports
Volume13
Issue number8
DOIs
StatePublished - Nov 24 2015
Externally publishedYes

Fingerprint

Simian Immunodeficiency Virus
Macaca
Lactobacillus
Viruses
Virus Diseases
Th17 Cells
Macaca mulatta
Indoleamine-Pyrrole 2,3,-Dioxygenase
HIV
Homeostasis
Mammals
Probiotics
Modulators
Enzymes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Vujkovic-Cvijin, I., Swainson, L. A., Chu, S. N., Ortiz, A. M., Santee, C. A., Petriello, A., ... McCune, J. M. (2015). Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques. Cell Reports, 13(8), 1589-1597. https://doi.org/10.1016/j.celrep.2015.10.026

Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques. / Vujkovic-Cvijin, Ivan; Swainson, Louise A.; Chu, Simon N.; Ortiz, Alexandra M.; Santee, Clark A.; Petriello, Annalise; Dunham, Richard M.; Fadrosh, Douglas W.; Lin, Din L.; Faruqi, Ali A.; Huang, Yong; Apetrei, Cristian; Pandrea, Ivona; Hecht, Frederick M.; Pilcher, Christopher D.; Klatt, Nichole; Brenchley, Jason M.; Lynch, Susan V.; McCune, Joseph M.

In: Cell Reports, Vol. 13, No. 8, 24.11.2015, p. 1589-1597.

Research output: Contribution to journalArticle

Vujkovic-Cvijin, I, Swainson, LA, Chu, SN, Ortiz, AM, Santee, CA, Petriello, A, Dunham, RM, Fadrosh, DW, Lin, DL, Faruqi, AA, Huang, Y, Apetrei, C, Pandrea, I, Hecht, FM, Pilcher, CD, Klatt, N, Brenchley, JM, Lynch, SV & McCune, JM 2015, 'Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques', Cell Reports, vol. 13, no. 8, pp. 1589-1597. https://doi.org/10.1016/j.celrep.2015.10.026
Vujkovic-Cvijin I, Swainson LA, Chu SN, Ortiz AM, Santee CA, Petriello A et al. Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques. Cell Reports. 2015 Nov 24;13(8):1589-1597. https://doi.org/10.1016/j.celrep.2015.10.026
Vujkovic-Cvijin, Ivan ; Swainson, Louise A. ; Chu, Simon N. ; Ortiz, Alexandra M. ; Santee, Clark A. ; Petriello, Annalise ; Dunham, Richard M. ; Fadrosh, Douglas W. ; Lin, Din L. ; Faruqi, Ali A. ; Huang, Yong ; Apetrei, Cristian ; Pandrea, Ivona ; Hecht, Frederick M. ; Pilcher, Christopher D. ; Klatt, Nichole ; Brenchley, Jason M. ; Lynch, Susan V. ; McCune, Joseph M. / Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques. In: Cell Reports. 2015 ; Vol. 13, No. 8. pp. 1589-1597.
@article{efbe52e6d3f242bcb10f31d217bb6bd9,
title = "Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques",
abstract = "Gut microbes can profoundly modulate mucosal barrier-promoting Th17 cells in mammals. A salient feature of HIV/simian immunodeficiency virus (SIV) immunopathogenesis is the loss of Th17 cells, which has been linked to increased activity of the immunomodulatory enzyme, indoleamine 2,3-dioxygenase 1 (IDO 1). The role of gut microbes in this system remains unknown, and the SIV-infected rhesus macaque provides a well-described model for HIV-associated Th17 loss and mucosal immune disruption. We observed a specific depletion of gut-resident Lactobacillus during acute and chronic SIV infection of rhesus macaques, which was also seen in early HIV-infected humans. This depletion in rhesus macaques correlated with increased IDO1 activity and Th17 loss. Macaques supplemented with a Lactobacillus-containing probiotic exhibited decreased IDO1 activity during chronic SIV infection. We propose that Lactobacillus species inhibit mammalian IDO1 and thus may help to preserve Th17 cells during pathogenic SIV infection, providing support for Lactobacillus species as modulators of mucosal immune homeostasis. Vujkovic-Cvijin et al. show that fecal Lactobacillus associates with control of the immunomodulatory indoleamine 2,3-dioxygenase (IDO) pathway, providing a link between the gut microbiome and mucosal immune homeostasis in the pathogenesis of SIV disease.",
author = "Ivan Vujkovic-Cvijin and Swainson, {Louise A.} and Chu, {Simon N.} and Ortiz, {Alexandra M.} and Santee, {Clark A.} and Annalise Petriello and Dunham, {Richard M.} and Fadrosh, {Douglas W.} and Lin, {Din L.} and Faruqi, {Ali A.} and Yong Huang and Cristian Apetrei and Ivona Pandrea and Hecht, {Frederick M.} and Pilcher, {Christopher D.} and Nichole Klatt and Brenchley, {Jason M.} and Lynch, {Susan V.} and McCune, {Joseph M.}",
year = "2015",
month = "11",
day = "24",
doi = "10.1016/j.celrep.2015.10.026",
language = "English (US)",
volume = "13",
pages = "1589--1597",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "8",

}

TY - JOUR

T1 - Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques

AU - Vujkovic-Cvijin, Ivan

AU - Swainson, Louise A.

AU - Chu, Simon N.

AU - Ortiz, Alexandra M.

AU - Santee, Clark A.

AU - Petriello, Annalise

AU - Dunham, Richard M.

AU - Fadrosh, Douglas W.

AU - Lin, Din L.

AU - Faruqi, Ali A.

AU - Huang, Yong

AU - Apetrei, Cristian

AU - Pandrea, Ivona

AU - Hecht, Frederick M.

AU - Pilcher, Christopher D.

AU - Klatt, Nichole

AU - Brenchley, Jason M.

AU - Lynch, Susan V.

AU - McCune, Joseph M.

PY - 2015/11/24

Y1 - 2015/11/24

N2 - Gut microbes can profoundly modulate mucosal barrier-promoting Th17 cells in mammals. A salient feature of HIV/simian immunodeficiency virus (SIV) immunopathogenesis is the loss of Th17 cells, which has been linked to increased activity of the immunomodulatory enzyme, indoleamine 2,3-dioxygenase 1 (IDO 1). The role of gut microbes in this system remains unknown, and the SIV-infected rhesus macaque provides a well-described model for HIV-associated Th17 loss and mucosal immune disruption. We observed a specific depletion of gut-resident Lactobacillus during acute and chronic SIV infection of rhesus macaques, which was also seen in early HIV-infected humans. This depletion in rhesus macaques correlated with increased IDO1 activity and Th17 loss. Macaques supplemented with a Lactobacillus-containing probiotic exhibited decreased IDO1 activity during chronic SIV infection. We propose that Lactobacillus species inhibit mammalian IDO1 and thus may help to preserve Th17 cells during pathogenic SIV infection, providing support for Lactobacillus species as modulators of mucosal immune homeostasis. Vujkovic-Cvijin et al. show that fecal Lactobacillus associates with control of the immunomodulatory indoleamine 2,3-dioxygenase (IDO) pathway, providing a link between the gut microbiome and mucosal immune homeostasis in the pathogenesis of SIV disease.

AB - Gut microbes can profoundly modulate mucosal barrier-promoting Th17 cells in mammals. A salient feature of HIV/simian immunodeficiency virus (SIV) immunopathogenesis is the loss of Th17 cells, which has been linked to increased activity of the immunomodulatory enzyme, indoleamine 2,3-dioxygenase 1 (IDO 1). The role of gut microbes in this system remains unknown, and the SIV-infected rhesus macaque provides a well-described model for HIV-associated Th17 loss and mucosal immune disruption. We observed a specific depletion of gut-resident Lactobacillus during acute and chronic SIV infection of rhesus macaques, which was also seen in early HIV-infected humans. This depletion in rhesus macaques correlated with increased IDO1 activity and Th17 loss. Macaques supplemented with a Lactobacillus-containing probiotic exhibited decreased IDO1 activity during chronic SIV infection. We propose that Lactobacillus species inhibit mammalian IDO1 and thus may help to preserve Th17 cells during pathogenic SIV infection, providing support for Lactobacillus species as modulators of mucosal immune homeostasis. Vujkovic-Cvijin et al. show that fecal Lactobacillus associates with control of the immunomodulatory indoleamine 2,3-dioxygenase (IDO) pathway, providing a link between the gut microbiome and mucosal immune homeostasis in the pathogenesis of SIV disease.

UR - http://www.scopus.com/inward/record.url?scp=84952872945&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84952872945&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2015.10.026

DO - 10.1016/j.celrep.2015.10.026

M3 - Article

C2 - 26586432

AN - SCOPUS:84952872945

VL - 13

SP - 1589

EP - 1597

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 8

ER -