Gut Microbiota Promotes Tumor Growth in Mice by Modulating Immune Response

Vrishketan Sethi, Saba Kurtom, Mohammad Tarique, Shweta Lavania, Zoe Malchiodi, Leonor Hellmund, Li Zhang, Umakant Sharma, Bhuwan Giri, Bharti Garg, Anthony Ferrantella, Selwyn M. Vickers, Sulagna Banerjee, Rajinder Dawra, Sabita Roy, Sundaram Ramakrishnan, Ashok Saluja, Vikas Dudeja

Research output: Contribution to journalArticlepeer-review

142 Scopus citations


We studied the effects of gut microbiome depletion by oral antibiotics on tumor growth in subcutaneous and liver metastases models of pancreatic cancer, colon cancer, and melanoma. Gut microbiome depletion significantly reduced tumor burden in all the models tested. However, depletion of gut microbiome did not reduce tumor growth in Rag1-knockout mice, which lack mature T and B cells. Flow cytometry analyses demonstrated that gut microbiome depletion led to significant increase in interferon gamma–producing T cells with corresponding decrease in interleukin 17A and interleukin 10–producing T cells. Our results suggest that gut microbiome modulation could emerge as a novel immunotherapeutic strategy.

Original languageEnglish (US)
Pages (from-to)33-37.e6
Issue number1
StatePublished - Jul 2018


  • Gut Bacteria
  • Immune Regulation
  • Metastases
  • Tumor Promotion

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


Dive into the research topics of 'Gut Microbiota Promotes Tumor Growth in Mice by Modulating Immune Response'. Together they form a unique fingerprint.

Cite this