Gut Microbiota Promotes Tumor Growth in Mice by Modulating Immune Response

Vrishketan Sethi, Saba Kurtom, Mohammad Tarique, Shweta Lavania, Zoe Malchiodi, Leonor Hellmund, Li Zhang, Umakant Sharma, Bhuwan Giri, Bharti Garg, Anthony Ferrantella, Selwyn M. Vickers, Sulagna Banerjee, Rajinder Dawra, Sabita Roy, Sundaram Ramakrishnan, Ashok Saluja, Vikas Dudeja

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We studied the effects of gut microbiome depletion by oral antibiotics on tumor growth in subcutaneous and liver metastases models of pancreatic cancer, colon cancer, and melanoma. Gut microbiome depletion significantly reduced tumor burden in all the models tested. However, depletion of gut microbiome did not reduce tumor growth in Rag1-knockout mice, which lack mature T and B cells. Flow cytometry analyses demonstrated that gut microbiome depletion led to significant increase in interferon gamma–producing T cells with corresponding decrease in interleukin 17A and interleukin 10–producing T cells. Our results suggest that gut microbiome modulation could emerge as a novel immunotherapeutic strategy.

Original languageEnglish (US)
Pages (from-to)33-37.e6
JournalGastroenterology
Volume155
Issue number1
DOIs
StatePublished - Jul 1 2018

Fingerprint

Growth
Neoplasms
T-Lymphocytes
Colonic Neoplasms
Interleukin-17
Interleukins
Tumor Burden
Pancreatic Neoplasms
Knockout Mice
Interferons
Melanoma
Flow Cytometry
B-Lymphocytes
Gastrointestinal Microbiome
Neoplasm Metastasis
Anti-Bacterial Agents
Liver

Keywords

  • Gut Bacteria
  • Immune Regulation
  • Metastases
  • Tumor Promotion

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Sethi, V., Kurtom, S., Tarique, M., Lavania, S., Malchiodi, Z., Hellmund, L., ... Dudeja, V. (2018). Gut Microbiota Promotes Tumor Growth in Mice by Modulating Immune Response. Gastroenterology, 155(1), 33-37.e6. https://doi.org/10.1053/j.gastro.2018.04.001

Gut Microbiota Promotes Tumor Growth in Mice by Modulating Immune Response. / Sethi, Vrishketan; Kurtom, Saba; Tarique, Mohammad; Lavania, Shweta; Malchiodi, Zoe; Hellmund, Leonor; Zhang, Li; Sharma, Umakant; Giri, Bhuwan; Garg, Bharti; Ferrantella, Anthony; Vickers, Selwyn M.; Banerjee, Sulagna; Dawra, Rajinder; Roy, Sabita; Ramakrishnan, Sundaram; Saluja, Ashok; Dudeja, Vikas.

In: Gastroenterology, Vol. 155, No. 1, 01.07.2018, p. 33-37.e6.

Research output: Contribution to journalArticle

Sethi, V, Kurtom, S, Tarique, M, Lavania, S, Malchiodi, Z, Hellmund, L, Zhang, L, Sharma, U, Giri, B, Garg, B, Ferrantella, A, Vickers, SM, Banerjee, S, Dawra, R, Roy, S, Ramakrishnan, S, Saluja, A & Dudeja, V 2018, 'Gut Microbiota Promotes Tumor Growth in Mice by Modulating Immune Response', Gastroenterology, vol. 155, no. 1, pp. 33-37.e6. https://doi.org/10.1053/j.gastro.2018.04.001
Sethi V, Kurtom S, Tarique M, Lavania S, Malchiodi Z, Hellmund L et al. Gut Microbiota Promotes Tumor Growth in Mice by Modulating Immune Response. Gastroenterology. 2018 Jul 1;155(1):33-37.e6. https://doi.org/10.1053/j.gastro.2018.04.001
Sethi, Vrishketan ; Kurtom, Saba ; Tarique, Mohammad ; Lavania, Shweta ; Malchiodi, Zoe ; Hellmund, Leonor ; Zhang, Li ; Sharma, Umakant ; Giri, Bhuwan ; Garg, Bharti ; Ferrantella, Anthony ; Vickers, Selwyn M. ; Banerjee, Sulagna ; Dawra, Rajinder ; Roy, Sabita ; Ramakrishnan, Sundaram ; Saluja, Ashok ; Dudeja, Vikas. / Gut Microbiota Promotes Tumor Growth in Mice by Modulating Immune Response. In: Gastroenterology. 2018 ; Vol. 155, No. 1. pp. 33-37.e6.
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