Gut microbiota perturbation is associated with acute sleep disturbance among rectal cancer patients

Velda J. González-Mercado, Anujit Sarkar, Frank J. Penedo, Josué Pérez-Santiago, Susan McMillan, Sara Janet Marrero, Miguel A. Marrero-Falcón, Cindy L. Munro

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Abstract

Cancer treatment-associated gut microbial perturbation/dysbiosis has been implicated in the pathobiology of sleep disturbance; however, evidence is scarce. Eighteen newly diagnosed rectal cancer patients (ages 52–81 years; 10 males) completed a sleep disturbance questionnaire and provided stool samples for 16s RNA gene sequencing during chemo-radiotherapy. Descriptive statistics, Wilcoxon test and regression analyses were computed. Regression analyses showed the Shannon's diversity index to be a significant factor associated with sleep disturbance. This preliminary work suggests that the biological “gut–brain axis” mechanism may be associated with symptoms of sleep disturbance.

Original languageEnglish (US)
Article numbere12915
JournalJournal of Sleep Research
DOIs
StateAccepted/In press - Jan 1 2019
Externally publishedYes

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Keywords

  • dysbiosis
  • sleep disturbance

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

González-Mercado, V. J., Sarkar, A., Penedo, F. J., Pérez-Santiago, J., McMillan, S., Marrero, S. J., Marrero-Falcón, M. A., & Munro, C. L. (Accepted/In press). Gut microbiota perturbation is associated with acute sleep disturbance among rectal cancer patients. Journal of Sleep Research, [e12915]. https://doi.org/10.1111/jsr.12915