Gut microbiome composition in the Hispanic Community Health Study/Study of Latinos is shaped by geographic relocation, environmental factors, and obesity

Robert C. Kaplan, Zheng Wang, Mykhaylo Usyk, Daniela Sotres-Alvarez, Martha L. Daviglus, Neil Schneiderman, Gregory A. Talavera, Marc D. Gellman, Bharat Thyagarajan, Jee Young Moon, Yoshiki Vázquez-Baeza, Daniel McDonald, Jessica S. Williams-Nguyen, Michael C. Wu, Kari E. North, Justin Shaffer, Christopher C. Sollecito, Qibin Qi, Carmen R. Isasi, Tao WangRob Knight, Robert D. Burk

Research output: Contribution to journalArticle

Abstract

Background: Hispanics living in the USA may have unrecognized potential birthplace and lifestyle influences on the gut microbiome. We report a cross-sectional analysis of 1674 participants from four centers of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), aged 18 to 74 years old at recruitment. Results: Amplicon sequencing of 16S rRNA gene V4 and fungal ITS1 fragments from self-collected stool samples indicate that the host microbiome is determined by sociodemographic and migration-related variables. Those who relocate from Latin America to the USA at an early age have reductions in Prevotella to Bacteroides ratios that persist across the life course. Shannon index of alpha diversity in fungi and bacteria is low in those who relocate to the USA in early life. In contrast, those who relocate to the USA during adulthood, over 45 years old, have high bacterial and fungal diversity and high Prevotella to Bacteroides ratios, compared to USA-born and childhood arrivals. Low bacterial diversity is associated in turn with obesity. Contrasting with prior studies, our study of the Latino population shows increasing Prevotella to Bacteroides ratio with greater obesity. Taxa within Acidaminococcus, Megasphaera, Ruminococcaceae, Coriobacteriaceae, Clostridiales, Christensenellaceae, YS2 (Cyanobacteria), and Victivallaceae are significantly associated with both obesity and earlier exposure to the USA, while Oscillospira and Anaerotruncus show paradoxical associations with both obesity and late-life introduction to the USA. Conclusions: Our analysis of the gut microbiome of Latinos demonstrates unique features that might be responsible for health disparities affecting Hispanics living in the USA.

Original languageEnglish (US)
Article number219
JournalGenome biology
Volume20
Issue number1
DOIs
StatePublished - Nov 1 2019

Fingerprint

community health
obesity
relocation
Hispanic Americans
environmental factor
digestive system
Obesity
Prevotella
environmental factors
Bacteroides
Health
Acidaminococcus
Megasphaera
lifestyle
Oscillospira
Community Health Centers
cyanobacterium
Coriobacteriaceae
Latin America
Clostridiales

Keywords

  • Epidemiology
  • Hispanic population
  • Microbiome
  • Mycobiome
  • Obesity

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology

Cite this

Gut microbiome composition in the Hispanic Community Health Study/Study of Latinos is shaped by geographic relocation, environmental factors, and obesity. / Kaplan, Robert C.; Wang, Zheng; Usyk, Mykhaylo; Sotres-Alvarez, Daniela; Daviglus, Martha L.; Schneiderman, Neil; Talavera, Gregory A.; Gellman, Marc D.; Thyagarajan, Bharat; Moon, Jee Young; Vázquez-Baeza, Yoshiki; McDonald, Daniel; Williams-Nguyen, Jessica S.; Wu, Michael C.; North, Kari E.; Shaffer, Justin; Sollecito, Christopher C.; Qi, Qibin; Isasi, Carmen R.; Wang, Tao; Knight, Rob; Burk, Robert D.

In: Genome biology, Vol. 20, No. 1, 219, 01.11.2019.

Research output: Contribution to journalArticle

Kaplan, RC, Wang, Z, Usyk, M, Sotres-Alvarez, D, Daviglus, ML, Schneiderman, N, Talavera, GA, Gellman, MD, Thyagarajan, B, Moon, JY, Vázquez-Baeza, Y, McDonald, D, Williams-Nguyen, JS, Wu, MC, North, KE, Shaffer, J, Sollecito, CC, Qi, Q, Isasi, CR, Wang, T, Knight, R & Burk, RD 2019, 'Gut microbiome composition in the Hispanic Community Health Study/Study of Latinos is shaped by geographic relocation, environmental factors, and obesity', Genome biology, vol. 20, no. 1, 219. https://doi.org/10.1186/s13059-019-1831-z
Kaplan, Robert C. ; Wang, Zheng ; Usyk, Mykhaylo ; Sotres-Alvarez, Daniela ; Daviglus, Martha L. ; Schneiderman, Neil ; Talavera, Gregory A. ; Gellman, Marc D. ; Thyagarajan, Bharat ; Moon, Jee Young ; Vázquez-Baeza, Yoshiki ; McDonald, Daniel ; Williams-Nguyen, Jessica S. ; Wu, Michael C. ; North, Kari E. ; Shaffer, Justin ; Sollecito, Christopher C. ; Qi, Qibin ; Isasi, Carmen R. ; Wang, Tao ; Knight, Rob ; Burk, Robert D. / Gut microbiome composition in the Hispanic Community Health Study/Study of Latinos is shaped by geographic relocation, environmental factors, and obesity. In: Genome biology. 2019 ; Vol. 20, No. 1.
@article{c4eeed2f22b341b386399359d59f82f0,
title = "Gut microbiome composition in the Hispanic Community Health Study/Study of Latinos is shaped by geographic relocation, environmental factors, and obesity",
abstract = "Background: Hispanics living in the USA may have unrecognized potential birthplace and lifestyle influences on the gut microbiome. We report a cross-sectional analysis of 1674 participants from four centers of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), aged 18 to 74 years old at recruitment. Results: Amplicon sequencing of 16S rRNA gene V4 and fungal ITS1 fragments from self-collected stool samples indicate that the host microbiome is determined by sociodemographic and migration-related variables. Those who relocate from Latin America to the USA at an early age have reductions in Prevotella to Bacteroides ratios that persist across the life course. Shannon index of alpha diversity in fungi and bacteria is low in those who relocate to the USA in early life. In contrast, those who relocate to the USA during adulthood, over 45 years old, have high bacterial and fungal diversity and high Prevotella to Bacteroides ratios, compared to USA-born and childhood arrivals. Low bacterial diversity is associated in turn with obesity. Contrasting with prior studies, our study of the Latino population shows increasing Prevotella to Bacteroides ratio with greater obesity. Taxa within Acidaminococcus, Megasphaera, Ruminococcaceae, Coriobacteriaceae, Clostridiales, Christensenellaceae, YS2 (Cyanobacteria), and Victivallaceae are significantly associated with both obesity and earlier exposure to the USA, while Oscillospira and Anaerotruncus show paradoxical associations with both obesity and late-life introduction to the USA. Conclusions: Our analysis of the gut microbiome of Latinos demonstrates unique features that might be responsible for health disparities affecting Hispanics living in the USA.",
keywords = "Epidemiology, Hispanic population, Microbiome, Mycobiome, Obesity",
author = "Kaplan, {Robert C.} and Zheng Wang and Mykhaylo Usyk and Daniela Sotres-Alvarez and Daviglus, {Martha L.} and Neil Schneiderman and Talavera, {Gregory A.} and Gellman, {Marc D.} and Bharat Thyagarajan and Moon, {Jee Young} and Yoshiki V{\'a}zquez-Baeza and Daniel McDonald and Williams-Nguyen, {Jessica S.} and Wu, {Michael C.} and North, {Kari E.} and Justin Shaffer and Sollecito, {Christopher C.} and Qibin Qi and Isasi, {Carmen R.} and Tao Wang and Rob Knight and Burk, {Robert D.}",
year = "2019",
month = "11",
day = "1",
doi = "10.1186/s13059-019-1831-z",
language = "English (US)",
volume = "20",
journal = "Genome Biology",
issn = "1465-6914",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Gut microbiome composition in the Hispanic Community Health Study/Study of Latinos is shaped by geographic relocation, environmental factors, and obesity

AU - Kaplan, Robert C.

AU - Wang, Zheng

AU - Usyk, Mykhaylo

AU - Sotres-Alvarez, Daniela

AU - Daviglus, Martha L.

AU - Schneiderman, Neil

AU - Talavera, Gregory A.

AU - Gellman, Marc D.

AU - Thyagarajan, Bharat

AU - Moon, Jee Young

AU - Vázquez-Baeza, Yoshiki

AU - McDonald, Daniel

AU - Williams-Nguyen, Jessica S.

AU - Wu, Michael C.

AU - North, Kari E.

AU - Shaffer, Justin

AU - Sollecito, Christopher C.

AU - Qi, Qibin

AU - Isasi, Carmen R.

AU - Wang, Tao

AU - Knight, Rob

AU - Burk, Robert D.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Background: Hispanics living in the USA may have unrecognized potential birthplace and lifestyle influences on the gut microbiome. We report a cross-sectional analysis of 1674 participants from four centers of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), aged 18 to 74 years old at recruitment. Results: Amplicon sequencing of 16S rRNA gene V4 and fungal ITS1 fragments from self-collected stool samples indicate that the host microbiome is determined by sociodemographic and migration-related variables. Those who relocate from Latin America to the USA at an early age have reductions in Prevotella to Bacteroides ratios that persist across the life course. Shannon index of alpha diversity in fungi and bacteria is low in those who relocate to the USA in early life. In contrast, those who relocate to the USA during adulthood, over 45 years old, have high bacterial and fungal diversity and high Prevotella to Bacteroides ratios, compared to USA-born and childhood arrivals. Low bacterial diversity is associated in turn with obesity. Contrasting with prior studies, our study of the Latino population shows increasing Prevotella to Bacteroides ratio with greater obesity. Taxa within Acidaminococcus, Megasphaera, Ruminococcaceae, Coriobacteriaceae, Clostridiales, Christensenellaceae, YS2 (Cyanobacteria), and Victivallaceae are significantly associated with both obesity and earlier exposure to the USA, while Oscillospira and Anaerotruncus show paradoxical associations with both obesity and late-life introduction to the USA. Conclusions: Our analysis of the gut microbiome of Latinos demonstrates unique features that might be responsible for health disparities affecting Hispanics living in the USA.

AB - Background: Hispanics living in the USA may have unrecognized potential birthplace and lifestyle influences on the gut microbiome. We report a cross-sectional analysis of 1674 participants from four centers of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), aged 18 to 74 years old at recruitment. Results: Amplicon sequencing of 16S rRNA gene V4 and fungal ITS1 fragments from self-collected stool samples indicate that the host microbiome is determined by sociodemographic and migration-related variables. Those who relocate from Latin America to the USA at an early age have reductions in Prevotella to Bacteroides ratios that persist across the life course. Shannon index of alpha diversity in fungi and bacteria is low in those who relocate to the USA in early life. In contrast, those who relocate to the USA during adulthood, over 45 years old, have high bacterial and fungal diversity and high Prevotella to Bacteroides ratios, compared to USA-born and childhood arrivals. Low bacterial diversity is associated in turn with obesity. Contrasting with prior studies, our study of the Latino population shows increasing Prevotella to Bacteroides ratio with greater obesity. Taxa within Acidaminococcus, Megasphaera, Ruminococcaceae, Coriobacteriaceae, Clostridiales, Christensenellaceae, YS2 (Cyanobacteria), and Victivallaceae are significantly associated with both obesity and earlier exposure to the USA, while Oscillospira and Anaerotruncus show paradoxical associations with both obesity and late-life introduction to the USA. Conclusions: Our analysis of the gut microbiome of Latinos demonstrates unique features that might be responsible for health disparities affecting Hispanics living in the USA.

KW - Epidemiology

KW - Hispanic population

KW - Microbiome

KW - Mycobiome

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=85074398106&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074398106&partnerID=8YFLogxK

U2 - 10.1186/s13059-019-1831-z

DO - 10.1186/s13059-019-1831-z

M3 - Article

C2 - 31672155

AN - SCOPUS:85074398106

VL - 20

JO - Genome Biology

JF - Genome Biology

SN - 1465-6914

IS - 1

M1 - 219

ER -