Guanfacine treatment of cognitive impairment in schizophrenia

Joseph I. Friedman; David N. Adler; Humberto D. Temporini; Eileen Kemether; Philip D. Harvey; Leonard White; Michael Parrella; Kenneth L. Davis

doi:10.1016/S0893-133X(01)00249-4

Guanfacine treatment of cognitive impairment in schizophrenia

Joseph I. Friedman, David N. Adler, Humberto D. Temporini, Eileen Kemether, Philip D. Harvey, Leonard White, Michael Parrella, Kenneth L. Davis

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Abstract

Norepinephrine plays a significant role in the working memory functions of the prefrontal cortex by its actions at alpha-2a noradrenergic receptors. Guanfacine has demonstrated efficacy in reversing working memory deficits in non-human primate. In the present study the effect of guanfacine adjunctive treatment to neuroleptics on the cognitive performance of schizophrenic patients was investigated in a four week, placebo-controlled, double-blind, parallel design trial. The primary analyses revealed no significant differences between guanfacine and placebo treatment; however, exploratory non-parametric statistics revealed some significant and some trend differences between guanfacine and placebo on spatial working memory test performance and CPT reaction time in those subjects treated with atypical neuroleptics.

Original language	English (US)
Pages (from-to)	402-409
Number of pages	8
Journal	Neuropsychopharmacology
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/S0893-133X(01)00249-4
State	Published - 2001
Externally published	Yes

Keywords

Clinical Trial
Cognitive
Guanfacine
Norepinephrine
Schizophrenia

ASJC Scopus subject areas

Pharmacology

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title = "Guanfacine treatment of cognitive impairment in schizophrenia",

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AU - White, Leonard

AU - Parrella, Michael

AU - Davis, Kenneth L.

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