Guanfacine treatment of cognitive impairment in schizophrenia

Joseph I. Friedman, David N. Adler, Humberto D. Temporini, Eileen Kemether, Philip D. Harvey, Leonard White, Michael Parrella, Kenneth L. Davis

Research output: Contribution to journalArticlepeer-review

107 Scopus citations


Norepinephrine plays a significant role in the working memory functions of the prefrontal cortex by its actions at alpha-2a noradrenergic receptors. Guanfacine has demonstrated efficacy in reversing working memory deficits in non-human primate. In the present study the effect of guanfacine adjunctive treatment to neuroleptics on the cognitive performance of schizophrenic patients was investigated in a four week, placebo-controlled, double-blind, parallel design trial. The primary analyses revealed no significant differences between guanfacine and placebo treatment; however, exploratory non-parametric statistics revealed some significant and some trend differences between guanfacine and placebo on spatial working memory test performance and CPT reaction time in those subjects treated with atypical neuroleptics.

Original languageEnglish (US)
Pages (from-to)402-409
Number of pages8
Issue number3
StatePublished - 2001
Externally publishedYes


  • Clinical Trial
  • Cognitive
  • Guanfacine
  • Norepinephrine
  • Schizophrenia

ASJC Scopus subject areas

  • Pharmacology


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