Growth retardation in the Lesch Nyhan syndrome

Jay S Skyler, F. A. Neelon, W. J. Arnold, W. N. Kelly, H. E. Lebovitz

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This study demonstrates that Lesch Nyhan syndrome patients exhibit significant growth retardation similar to that observed in other groups of patients with mental retardation. Endocrine studies indicate that this growth retardation cannot be attributed to pituitary or thyroid dysfunction. Serum somatomedin (sulphation factor) measurements were within the range of normal in 4 of the 5 patients studied. Therefore, the defect in growth and osseous maturation must be due to an abnormality in the end organ (cartilage).

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalActa Endocrinologica
Volume75
Issue number1
StatePublished - Jan 1 1974
Externally publishedYes

Fingerprint

Lesch-Nyhan Syndrome
Somatomedins
Growth
Intellectual Disability
Cartilage
Thyroid Gland
Reference Values
Serum

ASJC Scopus subject areas

  • Endocrinology

Cite this

Skyler, J. S., Neelon, F. A., Arnold, W. J., Kelly, W. N., & Lebovitz, H. E. (1974). Growth retardation in the Lesch Nyhan syndrome. Acta Endocrinologica, 75(1), 3-10.

Growth retardation in the Lesch Nyhan syndrome. / Skyler, Jay S; Neelon, F. A.; Arnold, W. J.; Kelly, W. N.; Lebovitz, H. E.

In: Acta Endocrinologica, Vol. 75, No. 1, 01.01.1974, p. 3-10.

Research output: Contribution to journalArticle

Skyler, JS, Neelon, FA, Arnold, WJ, Kelly, WN & Lebovitz, HE 1974, 'Growth retardation in the Lesch Nyhan syndrome', Acta Endocrinologica, vol. 75, no. 1, pp. 3-10.
Skyler JS, Neelon FA, Arnold WJ, Kelly WN, Lebovitz HE. Growth retardation in the Lesch Nyhan syndrome. Acta Endocrinologica. 1974 Jan 1;75(1):3-10.
Skyler, Jay S ; Neelon, F. A. ; Arnold, W. J. ; Kelly, W. N. ; Lebovitz, H. E. / Growth retardation in the Lesch Nyhan syndrome. In: Acta Endocrinologica. 1974 ; Vol. 75, No. 1. pp. 3-10.
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