Abstract
This study demonstrates that Lesch Nyhan syndrome patients exhibit significant growth retardation similar to that observed in other groups of patients with mental retardation. Endocrine studies indicate that this growth retardation cannot be attributed to pituitary or thyroid dysfunction. Serum somatomedin (sulphation factor) measurements were within the range of normal in 4 of the 5 patients studied. Therefore, the defect in growth and osseous maturation must be due to an abnormality in the end organ (cartilage).
| Original language | English |
|---|---|
| Pages (from-to) | 3-10 |
| Number of pages | 8 |
| Journal | Acta Endocrinologica |
| Volume | 75 |
| Issue number | 1 |
| State | Published - Jan 1 1974 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Endocrinology
Cite this
Growth retardation in the Lesch Nyhan syndrome. / Skyler, Jay S; Neelon, F. A.; Arnold, W. J.; Kelly, W. N.; Lebovitz, H. E.
In: Acta Endocrinologica, Vol. 75, No. 1, 01.01.1974, p. 3-10.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Growth retardation in the Lesch Nyhan syndrome
AU - Skyler, Jay S
AU - Neelon, F. A.
AU - Arnold, W. J.
AU - Kelly, W. N.
AU - Lebovitz, H. E.
PY - 1974/1/1
Y1 - 1974/1/1
N2 - This study demonstrates that Lesch Nyhan syndrome patients exhibit significant growth retardation similar to that observed in other groups of patients with mental retardation. Endocrine studies indicate that this growth retardation cannot be attributed to pituitary or thyroid dysfunction. Serum somatomedin (sulphation factor) measurements were within the range of normal in 4 of the 5 patients studied. Therefore, the defect in growth and osseous maturation must be due to an abnormality in the end organ (cartilage).
AB - This study demonstrates that Lesch Nyhan syndrome patients exhibit significant growth retardation similar to that observed in other groups of patients with mental retardation. Endocrine studies indicate that this growth retardation cannot be attributed to pituitary or thyroid dysfunction. Serum somatomedin (sulphation factor) measurements were within the range of normal in 4 of the 5 patients studied. Therefore, the defect in growth and osseous maturation must be due to an abnormality in the end organ (cartilage).
UR - http://www.scopus.com/inward/record.url?scp=0015962846&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015962846&partnerID=8YFLogxK
M3 - Article
C2 - 4363845
AN - SCOPUS:0015962846
VL - 75
SP - 3
EP - 10
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 1
ER -