Growth retardation in the Lesch Nyhan syndrome

J. S. Skyler, F. A. Neelon, W. J. Arnold, W. N. Kelly, H. E. Lebovitz

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


This study demonstrates that Lesch Nyhan syndrome patients exhibit significant growth retardation similar to that observed in other groups of patients with mental retardation. Endocrine studies indicate that this growth retardation cannot be attributed to pituitary or thyroid dysfunction. Serum somatomedin (sulphation factor) measurements were within the range of normal in 4 of the 5 patients studied. Therefore, the defect in growth and osseous maturation must be due to an abnormality in the end organ (cartilage).

Original languageEnglish (US)
Pages (from-to)3-10
Number of pages8
JournalUnknown Journal
Issue number1
StatePublished - 1974
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology


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