Growth retardation in the Lesch Nyhan syndrome

J. S. Skyler; F. A. Neelon; W. J. Arnold; W. N. Kelly; H. E. Lebovitz

doi:10.1530/acta.0.0750003

Growth retardation in the Lesch Nyhan syndrome

J. S. Skyler, F. A. Neelon, W. J. Arnold, W. N. Kelly, H. E. Lebovitz

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

This study demonstrates that Lesch Nyhan syndrome patients exhibit significant growth retardation similar to that observed in other groups of patients with mental retardation. Endocrine studies indicate that this growth retardation cannot be attributed to pituitary or thyroid dysfunction. Serum somatomedin (sulphation factor) measurements were within the range of normal in 4 of the 5 patients studied. Therefore, the defect in growth and osseous maturation must be due to an abnormality in the end organ (cartilage).

Original language	English (US)
Pages (from-to)	3-10
Number of pages	8
Journal	Unknown Journal
Volume	75
Issue number	1
DOIs	https://doi.org/10.1530/acta.0.0750003
State	Published - 1974
Externally published	Yes

ASJC Scopus subject areas

Endocrinology

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abstract = "This study demonstrates that Lesch Nyhan syndrome patients exhibit significant growth retardation similar to that observed in other groups of patients with mental retardation. Endocrine studies indicate that this growth retardation cannot be attributed to pituitary or thyroid dysfunction. Serum somatomedin (sulphation factor) measurements were within the range of normal in 4 of the 5 patients studied. Therefore, the defect in growth and osseous maturation must be due to an abnormality in the end organ (cartilage).",

author = "Skyler, {J. S.} and Neelon, {F. A.} and Arnold, {W. J.} and Kelly, {W. N.} and Lebovitz, {H. E.}",

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AU - Arnold, W. J.

AU - Kelly, W. N.

AU - Lebovitz, H. E.

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