Growth retardation in the Lesch Nyhan syndrome

J. S. Skyler, F. A. Neelon, W. J. Arnold, W. N. Kelly, H. E. Lebovitz

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

This study demonstrates that Lesch Nyhan syndrome patients exhibit significant growth retardation similar to that observed in other groups of patients with mental retardation. Endocrine studies indicate that this growth retardation cannot be attributed to pituitary or thyroid dysfunction. Serum somatomedin (sulphation factor) measurements were within the range of normal in 4 of the 5 patients studied. Therefore, the defect in growth and osseous maturation must be due to an abnormality in the end organ (cartilage).

Original languageEnglish (US)
Pages (from-to)3-10
Number of pages8
JournalUnknown Journal
Volume75
Issue number1
DOIs
StatePublished - 1974

ASJC Scopus subject areas

  • Endocrinology

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    Skyler, J. S., Neelon, F. A., Arnold, W. J., Kelly, W. N., & Lebovitz, H. E. (1974). Growth retardation in the Lesch Nyhan syndrome. Unknown Journal, 75(1), 3-10. https://doi.org/10.1530/acta.0.0750003