Growth regulation of human breast carcinoma occurs through regulated growth factor secretion

Marc E. Lippman; Robert B. Dickson; Edward P. Gelmann; Neal Rosen; Cornelius Knabbe; Susan Bates; Diane Bronzert; Karen Huff; Attan Kasid

doi:10.1002/jcb.240350102

Growth regulation of human breast carcinoma occurs through regulated growth factor secretion

Marc E. Lippman, Robert B. Dickson, Edward P. Gelmann, Neal Rosen, Cornelius Knabbe, Susan Bates, Diane Bronzert, Karen Huff, Attan Kasid

Medicine

Research output: Contribution to journal › Review article › peer-review

108 Scopus citations

Abstract

We describe studies on human breast cancer in which it is shown that specific growth factors (IGF‐I, TGFα, PDGF) are secreted by human breast cancer cells and likely to be involved in tumor growth and progression. These activities are regulated by estradiol in hormone‐dependent breast cancer and secreted constitutively by hormone‐independent cells. These growth factor activities can induce the growth of hormone‐dependent cells in vivo in athymic nude mice. Hormone‐dependent breast cancer cells also secrete TGFβ, a growth‐inhibitory substance, when treated with antiestrogens. TGFβ functions as a negative autocrine growth regulator and is responsible for some of the growth‐inhibitory effects of antiestrogens.

Original language	English (US)
Pages (from-to)	1-16
Number of pages	16
Journal	Journal of cellular biochemistry
Volume	35
Issue number	1
DOIs	https://doi.org/10.1002/jcb.240350102
State	Published - Sep 1987

Keywords

IGF‐I
PDGF
TGF
breast cancer
estrogen
growth factors

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jcb.240350102

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Growth regulation of human breast carcinoma occurs through regulated growth factor secretion. / Lippman, Marc E.; Dickson, Robert B.; Gelmann, Edward P.; Rosen, Neal; Knabbe, Cornelius; Bates, Susan; Bronzert, Diane; Huff, Karen; Kasid, Attan.

In: Journal of cellular biochemistry, Vol. 35, No. 1, 09.1987, p. 1-16.

Research output: Contribution to journal › Review article › peer-review

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abstract = "We describe studies on human breast cancer in which it is shown that specific growth factors (IGF‐I, TGFα, PDGF) are secreted by human breast cancer cells and likely to be involved in tumor growth and progression. These activities are regulated by estradiol in hormone‐dependent breast cancer and secreted constitutively by hormone‐independent cells. These growth factor activities can induce the growth of hormone‐dependent cells in vivo in athymic nude mice. Hormone‐dependent breast cancer cells also secrete TGFβ, a growth‐inhibitory substance, when treated with antiestrogens. TGFβ functions as a negative autocrine growth regulator and is responsible for some of the growth‐inhibitory effects of antiestrogens.",

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AU - Gelmann, Edward P.

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AU - Bates, Susan

AU - Bronzert, Diane

AU - Huff, Karen

AU - Kasid, Attan

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N2 - We describe studies on human breast cancer in which it is shown that specific growth factors (IGF‐I, TGFα, PDGF) are secreted by human breast cancer cells and likely to be involved in tumor growth and progression. These activities are regulated by estradiol in hormone‐dependent breast cancer and secreted constitutively by hormone‐independent cells. These growth factor activities can induce the growth of hormone‐dependent cells in vivo in athymic nude mice. Hormone‐dependent breast cancer cells also secrete TGFβ, a growth‐inhibitory substance, when treated with antiestrogens. TGFβ functions as a negative autocrine growth regulator and is responsible for some of the growth‐inhibitory effects of antiestrogens.

AB - We describe studies on human breast cancer in which it is shown that specific growth factors (IGF‐I, TGFα, PDGF) are secreted by human breast cancer cells and likely to be involved in tumor growth and progression. These activities are regulated by estradiol in hormone‐dependent breast cancer and secreted constitutively by hormone‐independent cells. These growth factor activities can induce the growth of hormone‐dependent cells in vivo in athymic nude mice. Hormone‐dependent breast cancer cells also secrete TGFβ, a growth‐inhibitory substance, when treated with antiestrogens. TGFβ functions as a negative autocrine growth regulator and is responsible for some of the growth‐inhibitory effects of antiestrogens.

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KW - growth factors

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Growth regulation of human breast carcinoma occurs through regulated growth factor secretion

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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