Growth regulation of human breast carcinoma occurs through regulated growth factor secretion

Marc E. Lippman, Robert B. Dickson, Edward P. Gelmann, Neal Rosen, Cornelius Knabbe, Susan Bates, Diane Bronzert, Karen Huff, Attan Kasid

Research output: Contribution to journalReview article

106 Scopus citations

Abstract

We describe studies on human breast cancer in which it is shown that specific growth factors (IGF‐I, TGFα, PDGF) are secreted by human breast cancer cells and likely to be involved in tumor growth and progression. These activities are regulated by estradiol in hormone‐dependent breast cancer and secreted constitutively by hormone‐independent cells. These growth factor activities can induce the growth of hormone‐dependent cells in vivo in athymic nude mice. Hormone‐dependent breast cancer cells also secrete TGFβ, a growth‐inhibitory substance, when treated with antiestrogens. TGFβ functions as a negative autocrine growth regulator and is responsible for some of the growth‐inhibitory effects of antiestrogens.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalJournal of cellular biochemistry
Volume35
Issue number1
DOIs
StatePublished - Sep 1987

Keywords

  • IGF‐I
  • PDGF
  • TGF
  • breast cancer
  • estrogen
  • growth factors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Lippman, M. E., Dickson, R. B., Gelmann, E. P., Rosen, N., Knabbe, C., Bates, S., Bronzert, D., Huff, K., & Kasid, A. (1987). Growth regulation of human breast carcinoma occurs through regulated growth factor secretion. Journal of cellular biochemistry, 35(1), 1-16. https://doi.org/10.1002/jcb.240350102