Abstract
By using as an experimental system the induction of growth of a cloned, antigen:Ia-reactive helper T cell line by an antigen receptor-specific monoclonal antibody, we demonstrated that growth requires two essential co-factors, exogenously produced IL 1 and endogenously produced IL 2. The primary role of the IL 1 is in the expression of receptors on the T cell surface for IL 2, rather than for promoting the synthesis of IL 2. The use of a clone-specific activating monoclonal antibody at nanogram amounts to activate a cloned helper T cell should allow a detailed characterization of T cell activation via antigen receptor cross-linking.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1339-1345 |
| Number of pages | 7 |
| Journal | Journal of Immunology |
| Volume | 133 |
| Issue number | 3 |
| State | Published - Oct 11 1984 |
| Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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Kaye, J., Gillis, S., Mizel, S. B., Shevach, E. M., Malek, T. R., Dinarello, C. A., Lachman, L. B., & Janeway, C. A. (1984). Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: Interleukin 1 is required fo the expression of receptors for interleukin 2. Journal of Immunology, 133(3), 1339-1345.