Growth hormone response to growth hormone-releasing factor in depression

K. Ranga R. Krishnan, Ananth N. Manepalli, James C. Ritchie, Krishniah Rayasam, Mary Lou Melville, Michael O. Thorner, Jean E. Rivier, Wylie W. Vale, Charles B. Nemeroff

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


A blunted growth hormone (GH) response to clonidine and other pharmacologic stimuli has been reported in patients with depression. This blunted growth hormone response to clonidine had led to the speculation that there is a central alpha-2 adrenergic receptor subsensitivity in depression. This hypothesis is based on the assumption that the pituitary somatotroph response to growth hormone-releasing factor (GHRF) is not altered in depression. In the present preliminary study, the somatotroph response to GHRF in depressed patients and normal controls has been evaluated in four depressed patients and four age- and sex-matched controls. The GH response to GRF is highly variable both in normal individuals and in the depressed patients studied. Larger numbers of patients and controls must be studied before any definitive conclusions can be drawn about GH responses to GRF in depressed patients.

Original languageEnglish (US)
Pages (from-to)113-116
Number of pages4
Issue numberSUPPL. 1
StatePublished - 1988
Externally publishedYes


  • Depression
  • Growth hormone (GH)
  • Growth hormone-releasing factor (GHRF)

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Growth hormone response to growth hormone-releasing factor in depression'. Together they form a unique fingerprint.

Cite this