Growth hormone response to growth hormone releasing factor in Alzheimer’s disease

Charles B. Nememff, K. Ranga Rama Krishnan, Beth M. Belkin, James C. Ritchie, Christopher Clark, Wylie W. Vale, Jam E. Rivier, Michael O. Thurner

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Because of the well-established reduction in the concentration of somatostatin in several brain areas of patients with histologically verified Alzheimer's disease, we sought to determine if growth hormone (GH) secretion is altered in Alzheimer's disease. In order to study this, we assessed the GH response to growth hormone releasing factor (GRF) in 8 patients with Alzheimer's disease and 8 age-matched controls. Although there was no difference between the magnitude of the GRF-induced GH response (Δ max GH response or area under the curve) between the Alzheimer's disease patients and the controls, the Alzheimer's patients exhibited a delayed GH response to GRF.

Original languageEnglish (US)
Pages (from-to)663-666
Number of pages4
JournalNeuroendocrinology
Volume50
Issue number6
DOIs
StatePublished - 1989
Externally publishedYes

Keywords

  • Neurodegenerative disorders
  • Neuropeptides

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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