Growth hormone response to clonidine in adversely reared young adult primates: Relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations

Jeremy D. Coplan, E. L P Smith, Ronald C. Trost, Bruce A. Scharf, Margaret Altemus, Loring Bjornson, Michael J. Owens, Jack M. Gorman, Charles Nemeroff, Leonard A. Rosenblum

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A reduction of the growth hormone (GH) response to the α2 adrenergic agonist clonidine is a neuroendocrine abnormality observed with reasonable consistency among human patients with mood and anxiety disorders. In previous primate studies, in comparison to predictably reared controls, monkeys exposed as infants to maternal variable foraging demand (VFD) rearing exhibited persistent elevations of cerebrospinal fluid (CSF) corticotropin- releasing factor (CRF), as well as other biological disturbances. As CRF has been demonstrated to inhibit GH release, the authors hypothesized that within VFD-reared subjects, animals with relatively high CRF concentrations would exhibit relatively diminished GH responses to clonidine. The current study examined the relationship between the GH response to clonidine in VFD-reared adult primates in relation to a range of both juvenile and follow-up CSF CRF concentrations. Nine bonnet macaques (Macaca radiata) were given ascending dosages of clonidine under ketamine anesthesia. Plasma samples for GH-like immunoreactivity were obtained throughout the session. A significant positive correlation was noted between juvenile CSF CRF concentrations and the levels of the neuropeptide observed in young adults. The mean of the serial CSF CRF concentrations exhibited a significant inverse relationship towards the GH response to clonidine in young adulthood, with relatively high CSF CRF associated with relatively attenuated GH responses to clonidine. These data raise the possibility that a reduced GH response to clonidine may inversely reflect trait-like increases of central nervous system (CNS) CRF activity. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)93-102
Number of pages10
JournalPsychiatry Research
Volume95
Issue number2
DOIs
StatePublished - Aug 21 2000
Externally publishedYes

Fingerprint

Corticotropin-Releasing Hormone
Clonidine
Primates
Growth Hormone
Cerebrospinal Fluid
Young Adult
Macaca radiata
Adrenergic Agonists
Ketamine
Anxiety Disorders
Neuropeptides
Mood Disorders
Haplorhini
Anesthesia
Central Nervous System
Mothers

Keywords

  • Alpha-2 adrenergic receptor
  • Bonnet macaques
  • Corticotropin-releasing factor
  • Psychoendocrinology

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Growth hormone response to clonidine in adversely reared young adult primates : Relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations. / Coplan, Jeremy D.; Smith, E. L P; Trost, Ronald C.; Scharf, Bruce A.; Altemus, Margaret; Bjornson, Loring; Owens, Michael J.; Gorman, Jack M.; Nemeroff, Charles; Rosenblum, Leonard A.

In: Psychiatry Research, Vol. 95, No. 2, 21.08.2000, p. 93-102.

Research output: Contribution to journalArticle

Coplan, Jeremy D. ; Smith, E. L P ; Trost, Ronald C. ; Scharf, Bruce A. ; Altemus, Margaret ; Bjornson, Loring ; Owens, Michael J. ; Gorman, Jack M. ; Nemeroff, Charles ; Rosenblum, Leonard A. / Growth hormone response to clonidine in adversely reared young adult primates : Relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations. In: Psychiatry Research. 2000 ; Vol. 95, No. 2. pp. 93-102.
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