Growth hormone-releasing hormone and extra-pituitary tumorigenesis: Therapeutic and diagnostic applications of growth hormone-releasing hormone antagonists

Hippokratis Kiaris, Michael Koutsilieris, Anastasios Kalofoutis, Andrew V. Schally

Research output: Contribution to journalReview article

33 Scopus citations

Abstract

Growth hormone-releasing hormone (GHRH) regulates growth hormone release from the pituitary. However, in addition to this neuroendocrine action, much evidence implies an additional role for GHRH in carcinogenesis in non-pituitary tissues. This role of GHRH in cancer development appears to be due to the operation of several mechanisms, which involve the regulation of the growth hormone-dependent hepatic insulin-like growth factor I (IGF-I) production, tumoural IGF-I and IGF-II secretion and direct action of GHRH on tumour cells by autocrine and/or paracrine pathways. This review summarises the available information regarding the role of GHRH in tumorigenesis with special emphasis on the direct action of GHRH in primary and experimental cancers.

Original languageEnglish (US)
Pages (from-to)1385-1394
Number of pages10
JournalExpert opinion on investigational drugs
Volume12
Issue number8
DOIs
StatePublished - Aug 1 2003
Externally publishedYes

Keywords

  • Anticancer therapy
  • Autocrine
  • GHRH
  • GHRH receptor
  • Neuropeptides

ASJC Scopus subject areas

  • Pharmacology

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