TY - JOUR
T1 - Growth hormone-releasing hormone and extra-pituitary tumorigenesis
T2 - Therapeutic and diagnostic applications of growth hormone-releasing hormone antagonists
AU - Kiaris, Hippokratis
AU - Koutsilieris, Michael
AU - Kalofoutis, Anastasios
AU - Schally, Andrew V.
PY - 2003/8/1
Y1 - 2003/8/1
N2 - Growth hormone-releasing hormone (GHRH) regulates growth hormone release from the pituitary. However, in addition to this neuroendocrine action, much evidence implies an additional role for GHRH in carcinogenesis in non-pituitary tissues. This role of GHRH in cancer development appears to be due to the operation of several mechanisms, which involve the regulation of the growth hormone-dependent hepatic insulin-like growth factor I (IGF-I) production, tumoural IGF-I and IGF-II secretion and direct action of GHRH on tumour cells by autocrine and/or paracrine pathways. This review summarises the available information regarding the role of GHRH in tumorigenesis with special emphasis on the direct action of GHRH in primary and experimental cancers.
AB - Growth hormone-releasing hormone (GHRH) regulates growth hormone release from the pituitary. However, in addition to this neuroendocrine action, much evidence implies an additional role for GHRH in carcinogenesis in non-pituitary tissues. This role of GHRH in cancer development appears to be due to the operation of several mechanisms, which involve the regulation of the growth hormone-dependent hepatic insulin-like growth factor I (IGF-I) production, tumoural IGF-I and IGF-II secretion and direct action of GHRH on tumour cells by autocrine and/or paracrine pathways. This review summarises the available information regarding the role of GHRH in tumorigenesis with special emphasis on the direct action of GHRH in primary and experimental cancers.
KW - Anticancer therapy
KW - Autocrine
KW - GHRH
KW - GHRH receptor
KW - Neuropeptides
UR - http://www.scopus.com/inward/record.url?scp=0041633498&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0041633498&partnerID=8YFLogxK
U2 - 10.1517/13543784.12.8.1385
DO - 10.1517/13543784.12.8.1385
M3 - Review article
C2 - 12882623
AN - SCOPUS:0041633498
VL - 12
SP - 1385
EP - 1394
JO - Expert Opinion on Investigational Drugs
JF - Expert Opinion on Investigational Drugs
SN - 1354-3784
IS - 8
ER -
