Growth hormone-releasing factor stimulation test in depression

K. R.R. Krishnan, A. N. Manepalli, J. C. Ritchie, K. Rayasam, M. L. Melville, G. Daughtry, M. O. Thorner, J. E. Rivier, W. W. Vale, C. B. Nemeroff, B. J. Carroll

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

The authors administered the growth hormone-releasing factor (GRF) stimulation test to 19 patients with major depression and 19 age- and sex-matched control subjects to test the hypothesis that a blunted growth hormone (GH) response to clonidine reflects a central α2-adrenergic receptor subsensitivity in depression. GH response to GRF was significantly higher in patients with depression than in control subjects. This group difference was mainly attributable to three of the 19 depressed patients who exhibited markedly high GH responses to GRF. These results suggest that the blunted GH response to clonidine seen in patients with depression is not due to a pituitary defect in GH secretion.

Original languageEnglish (US)
Pages (from-to)90-92
Number of pages3
JournalAmerican Journal of Psychiatry
Volume145
Issue number1
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Krishnan, K. R. R., Manepalli, A. N., Ritchie, J. C., Rayasam, K., Melville, M. L., Daughtry, G., Thorner, M. O., Rivier, J. E., Vale, W. W., Nemeroff, C. B., & Carroll, B. J. (1988). Growth hormone-releasing factor stimulation test in depression. American Journal of Psychiatry, 145(1), 90-92. https://doi.org/10.1176/ajp.145.1.90