Growth hormone-releasing activity in the hypothalamus of animals of different species

Eugenio E. Muller, Shinji Sawano, Andrew V Schally

Research output: Contribution to journalArticle

18 Scopus citations


Hypothalamic extracts from the dog, rabbit, mouse, kitten, pigeon, and frog were found to decrease the growth hormone (GH) content of rat pituitary glands. Comparable cerebral cortical extracts were completely inactive in this test. These results broaden previous observations on the existence of a GH-releasing factor (GRF) in the hypothalami of mammals and show the presence of GRF activity in birds and amphibians.

Original languageEnglish
Pages (from-to)349-352
Number of pages4
JournalGeneral and Comparative Endocrinology
Issue number3
StatePublished - Dec 1 1967
Externally publishedYes


ASJC Scopus subject areas

  • Endocrinology

Cite this