Growth Hormone Release Inhibiting Hormone: Actions on Thyrotrophin and Prolactin Secretion after Thyrotrophin-releasing Hormone

D. Carr, A. Gomez-Pan, D. R. Weightman, V. C.M. Roy, R. Hall, G. M. Besser, M. O. Thorner, A. S. Mcneilly, A. V. Schally, A. J. Kastin, D. H. Coy

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

The hypothalamic tetradecapeptide growth hormone release inhibiting hormone (GH-RIH) blocked the thyrotrophin response to thyrotrophin releasing hormone (TRH) in normal people and in patients with primary hypothyroidism. This inhibition was dose related. The TRH induced prolactin release was not affected by GH-RIH. This dissociation of the thyrotrophin and prolactin responses to TRH by GH-RIH suggests that there are different mechanisms for release of thyrotrophin and prolactin and that only the former is affected by GH-RIH.

Original languageEnglish (US)
Pages (from-to)67-69
Number of pages3
JournalBritish medical journal
Volume3
Issue number5975
DOIs
StatePublished - Jul 12 1975

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Growth Hormone Release Inhibiting Hormone: Actions on Thyrotrophin and Prolactin Secretion after Thyrotrophin-releasing Hormone'. Together they form a unique fingerprint.

  • Cite this

    Carr, D., Gomez-Pan, A., Weightman, D. R., Roy, V. C. M., Hall, R., Besser, G. M., Thorner, M. O., Mcneilly, A. S., Schally, A. V., Kastin, A. J., & Coy, D. H. (1975). Growth Hormone Release Inhibiting Hormone: Actions on Thyrotrophin and Prolactin Secretion after Thyrotrophin-releasing Hormone. British medical journal, 3(5975), 67-69. https://doi.org/10.1136/bmj.3.5975.67