Growth factors in breast cancer: Mitogenesis to transformation

Robert B. Dickson, Michael D. Johnson, Mozeena Bano, Eric Shi, Junichi Kurebayashi, Barbara Ziff, Isabel Martinez-Lacaci, Laufey T. Amundadottir, Marc E. Lippman

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


While endocrine steroid hormones have been known for many years to regulate normal and malignant mammary epithelium, recent studies have led to an appreciation of polypeptide growth factors as locally-acting autocrine and paracrine effectors. In the current article we summarize what is known about growth factor regulation and action in the normal mammary gland and about perturbations of the steroid-growth factor interplay as cancer progresses. A major theme is that oncogenic activation modulates both regulation of production and function of growth factors in the mammary gland.

Original languageEnglish (US)
Pages (from-to)69-78
Number of pages10
JournalJournal of Steroid Biochemistry and Molecular Biology
Issue number1-3
StatePublished - Sep 1992

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology


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