Growth factors in breast cancer: Mitogenesis to transformation

Robert B. Dickson; Michael D. Johnson; Mozeena Bano; Eric Shi; Junichi Kurebayashi; Barbara Ziff; Isabel Martinez-Lacaci; Laufey T. Amundadottir; Marc E. Lippman

doi:10.1016/0960-0760(92)90189-P

Growth factors in breast cancer: Mitogenesis to transformation

Robert B. Dickson, Michael D. Johnson, Mozeena Bano, Eric Shi, Junichi Kurebayashi, Barbara Ziff, Isabel Martinez-Lacaci, Laufey T. Amundadottir, Marc E. Lippman

Medicine

Research output: Contribution to journal › Article

44 Scopus citations

Abstract

While endocrine steroid hormones have been known for many years to regulate normal and malignant mammary epithelium, recent studies have led to an appreciation of polypeptide growth factors as locally-acting autocrine and paracrine effectors. In the current article we summarize what is known about growth factor regulation and action in the normal mammary gland and about perturbations of the steroid-growth factor interplay as cancer progresses. A major theme is that oncogenic activation modulates both regulation of production and function of growth factors in the mammary gland.

Original language	English (US)
Pages (from-to)	69-78
Number of pages	10
Journal	Journal of Steroid Biochemistry and Molecular Biology
Volume	43
Issue number	1-3
DOIs	https://doi.org/10.1016/0960-0760(92)90189-P
State	Published - Sep 1992

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Molecular Medicine
Molecular Biology
Endocrinology
Clinical Biochemistry
Cell Biology

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Dickson, R. B., Johnson, M. D., Bano, M., Shi, E., Kurebayashi, J., Ziff, B., Martinez-Lacaci, I., Amundadottir, L. T., & Lippman, M. E. (1992). Growth factors in breast cancer: Mitogenesis to transformation. Journal of Steroid Biochemistry and Molecular Biology, 43(1-3), 69-78. https://doi.org/10.1016/0960-0760(92)90189-P

Growth factors in breast cancer : Mitogenesis to transformation. / Dickson, Robert B.; Johnson, Michael D.; Bano, Mozeena; Shi, Eric; Kurebayashi, Junichi; Ziff, Barbara; Martinez-Lacaci, Isabel; Amundadottir, Laufey T.; Lippman, Marc E.

In: Journal of Steroid Biochemistry and Molecular Biology, Vol. 43, No. 1-3, 09.1992, p. 69-78.

Research output: Contribution to journal › Article

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