TY - JOUR
T1 - Growth factors in breast cancer
T2 - Mitogenesis to transformation
AU - Dickson, Robert B.
AU - Johnson, Michael D.
AU - Bano, Mozeena
AU - Shi, Eric
AU - Kurebayashi, Junichi
AU - Ziff, Barbara
AU - Martinez-Lacaci, Isabel
AU - Amundadottir, Laufey T.
AU - Lippman, Marc E.
PY - 1992/9
Y1 - 1992/9
N2 - While endocrine steroid hormones have been known for many years to regulate normal and malignant mammary epithelium, recent studies have led to an appreciation of polypeptide growth factors as locally-acting autocrine and paracrine effectors. In the current article we summarize what is known about growth factor regulation and action in the normal mammary gland and about perturbations of the steroid-growth factor interplay as cancer progresses. A major theme is that oncogenic activation modulates both regulation of production and function of growth factors in the mammary gland.
AB - While endocrine steroid hormones have been known for many years to regulate normal and malignant mammary epithelium, recent studies have led to an appreciation of polypeptide growth factors as locally-acting autocrine and paracrine effectors. In the current article we summarize what is known about growth factor regulation and action in the normal mammary gland and about perturbations of the steroid-growth factor interplay as cancer progresses. A major theme is that oncogenic activation modulates both regulation of production and function of growth factors in the mammary gland.
UR - http://www.scopus.com/inward/record.url?scp=0026701693&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026701693&partnerID=8YFLogxK
U2 - 10.1016/0960-0760(92)90189-P
DO - 10.1016/0960-0760(92)90189-P
M3 - Article
C2 - 1525068
AN - SCOPUS:0026701693
VL - 43
SP - 69
EP - 78
JO - Journal of Steroid Biochemistry and Molecular Biology
JF - Journal of Steroid Biochemistry and Molecular Biology
SN - 0960-0760
IS - 1-3
ER -
