Growth factors in breast cancer: Mitogenesis to transformation

Robert B. Dickson, Michael D. Johnson, Mozeena Bano, Eric Shi, Junichi Kurebayashi, Barbara Ziff, Isabel Martinez-Lacaci, Laufey T. Amundadottir, Marc E Lippman

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

While endocrine steroid hormones have been known for many years to regulate normal and malignant mammary epithelium, recent studies have led to an appreciation of polypeptide growth factors as locally-acting autocrine and paracrine effectors. In the current article we summarize what is known about growth factor regulation and action in the normal mammary gland and about perturbations of the steroid-growth factor interplay as cancer progresses. A major theme is that oncogenic activation modulates both regulation of production and function of growth factors in the mammary gland.

Original languageEnglish
Pages (from-to)69-78
Number of pages10
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume43
Issue number1-3
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Intercellular Signaling Peptides and Proteins
Breast Neoplasms
Human Mammary Glands
Steroid hormones
Steroids
Breast
Epithelium
Chemical activation
Hormones
Peptides
Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Dickson, R. B., Johnson, M. D., Bano, M., Shi, E., Kurebayashi, J., Ziff, B., ... Lippman, M. E. (1992). Growth factors in breast cancer: Mitogenesis to transformation. Journal of Steroid Biochemistry and Molecular Biology, 43(1-3), 69-78. https://doi.org/10.1016/0960-0760(92)90189-P

Growth factors in breast cancer : Mitogenesis to transformation. / Dickson, Robert B.; Johnson, Michael D.; Bano, Mozeena; Shi, Eric; Kurebayashi, Junichi; Ziff, Barbara; Martinez-Lacaci, Isabel; Amundadottir, Laufey T.; Lippman, Marc E.

In: Journal of Steroid Biochemistry and Molecular Biology, Vol. 43, No. 1-3, 01.01.1992, p. 69-78.

Research output: Contribution to journalArticle

Dickson, RB, Johnson, MD, Bano, M, Shi, E, Kurebayashi, J, Ziff, B, Martinez-Lacaci, I, Amundadottir, LT & Lippman, ME 1992, 'Growth factors in breast cancer: Mitogenesis to transformation', Journal of Steroid Biochemistry and Molecular Biology, vol. 43, no. 1-3, pp. 69-78. https://doi.org/10.1016/0960-0760(92)90189-P
Dickson, Robert B. ; Johnson, Michael D. ; Bano, Mozeena ; Shi, Eric ; Kurebayashi, Junichi ; Ziff, Barbara ; Martinez-Lacaci, Isabel ; Amundadottir, Laufey T. ; Lippman, Marc E. / Growth factors in breast cancer : Mitogenesis to transformation. In: Journal of Steroid Biochemistry and Molecular Biology. 1992 ; Vol. 43, No. 1-3. pp. 69-78.
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