Growth factors and cytokines in wound healing

Stephan Barrientos, Olivera Stojadinovic, Michael S. Golinko, Harold Brem, Marjana Tomic-Canic

Research output: Contribution to journalArticle

1519 Citations (Scopus)

Abstract

Wound healing is an evolutionarily conserved, complex, multicellular process that, in skin, aims at barrier restoration. This process involves the coordinated efforts of several cell types including keratinocytes, fibroblasts, endothelial cells, macrophages, and platelets. The migration, infiltration, proliferation, and differentiation of these cells will culminate in an inflammatory response, the formation of new tissue and ultimately wound closure. This complex process is executed and regulated by an equally complex signaling network involving numerous growth factors, cytokines and chemokines. Of particular importance is the epidermal growth factor (EGF) family, transforming growth factor beta (TGF-β) family, fibroblast growth factor (FGF) family, vascular endothelial growth factor (VEGF), granulocyte macrophage colony stimulating factor (GM-CSF), platelet-derived growth factor (PDGF), connective tissue growth factor (CTGF), interleukin (IL) family, and tumor nerosis factor-α family. Currently, patients are treated by three growth factors: PDGF-BB, bFGF, and GM-CSF. Only PDGF-BB has successfully completed randomized clinical trials in the Unites States. With gene therapy now in clinical trial and the discovery of biodegradable polymers, fibrin mesh, and human collagen serving as potential delivery systems other growth factors may soon be available to patients. This review will focus on the specific roles of these growth factors and cytokines during the wound healing process.

Original languageEnglish
Pages (from-to)585-601
Number of pages17
JournalWound Repair and Regeneration
Volume16
Issue number5
DOIs
StatePublished - Sep 1 2008
Externally publishedYes

Fingerprint

Wound Healing
Intercellular Signaling Peptides and Proteins
Cytokines
Granulocyte-Macrophage Colony-Stimulating Factor
Connective Tissue Growth Factor
Fibroblast Growth Factors
Interleukins
Platelet-Derived Growth Factor
Fibrin
Keratinocytes
Chemokines
Epidermal Growth Factor
Transforming Growth Factor beta
Genetic Therapy
Vascular Endothelial Growth Factor A
Cell Differentiation
Polymers
Collagen
Blood Platelets
Randomized Controlled Trials

ASJC Scopus subject areas

  • Dermatology
  • Surgery

Cite this

Growth factors and cytokines in wound healing. / Barrientos, Stephan; Stojadinovic, Olivera; Golinko, Michael S.; Brem, Harold; Tomic-Canic, Marjana.

In: Wound Repair and Regeneration, Vol. 16, No. 5, 01.09.2008, p. 585-601.

Research output: Contribution to journalArticle

Barrientos, S, Stojadinovic, O, Golinko, MS, Brem, H & Tomic-Canic, M 2008, 'Growth factors and cytokines in wound healing', Wound Repair and Regeneration, vol. 16, no. 5, pp. 585-601. https://doi.org/10.1111/j.1524-475X.2008.00410.x
Barrientos, Stephan ; Stojadinovic, Olivera ; Golinko, Michael S. ; Brem, Harold ; Tomic-Canic, Marjana. / Growth factors and cytokines in wound healing. In: Wound Repair and Regeneration. 2008 ; Vol. 16, No. 5. pp. 585-601.
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