Abstract
Most hearing loss results from lesions of the sensory cells and/or of the neurons of the auditory part of the inner ear. There is currently no treatment able to stop the progression of a hearing loss or to restore a lost auditory function. In this paper, we review the progress which has been made with respect to the regeneration and the protection of the hair cells and of the auditory neurons in the cochlea. In particular, we emphasize the control by growth factors of the protection/repair mechanisms of the neurosensory structures within the inner ear, in the prospect of the possible clinical use of these molecules. Finally, we discuss the different approaches which can be used to deliver these therapeutic agents to the inner ear. Copyright (C) 1999 Elsevier Science Ireland Ltd.
| Original language | English |
|---|---|
| Journal | International Journal of Pediatric Otorhinolaryngology |
| Volume | 49 |
| Issue number | SUPPL. 1 |
| DOIs | |
| State | Published - Oct 5 1999 |
| Externally published | Yes |
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Keywords
- Cell culture
- Cochlea
- Hearing impairment
- Inner ear
- Ototoxicity
ASJC Scopus subject areas
- Otorhinolaryngology
- Pediatrics, Perinatology, and Child Health
- Pulmonary and Respiratory Medicine
- Surgery
Cite this
Growth factor therapy to the damaged inner ear : Clinical propects. / Malgrange, Brigitte; Rigo, Jean Michel; Van De Water, Thomas R; Staecker, Hinrich; Moonen, Gustave; Lefebvre, Philippe P.
In: International Journal of Pediatric Otorhinolaryngology, Vol. 49, No. SUPPL. 1, 05.10.1999.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Growth factor therapy to the damaged inner ear
T2 - Clinical propects
AU - Malgrange, Brigitte
AU - Rigo, Jean Michel
AU - Van De Water, Thomas R
AU - Staecker, Hinrich
AU - Moonen, Gustave
AU - Lefebvre, Philippe P.
PY - 1999/10/5
Y1 - 1999/10/5
N2 - Most hearing loss results from lesions of the sensory cells and/or of the neurons of the auditory part of the inner ear. There is currently no treatment able to stop the progression of a hearing loss or to restore a lost auditory function. In this paper, we review the progress which has been made with respect to the regeneration and the protection of the hair cells and of the auditory neurons in the cochlea. In particular, we emphasize the control by growth factors of the protection/repair mechanisms of the neurosensory structures within the inner ear, in the prospect of the possible clinical use of these molecules. Finally, we discuss the different approaches which can be used to deliver these therapeutic agents to the inner ear. Copyright (C) 1999 Elsevier Science Ireland Ltd.
AB - Most hearing loss results from lesions of the sensory cells and/or of the neurons of the auditory part of the inner ear. There is currently no treatment able to stop the progression of a hearing loss or to restore a lost auditory function. In this paper, we review the progress which has been made with respect to the regeneration and the protection of the hair cells and of the auditory neurons in the cochlea. In particular, we emphasize the control by growth factors of the protection/repair mechanisms of the neurosensory structures within the inner ear, in the prospect of the possible clinical use of these molecules. Finally, we discuss the different approaches which can be used to deliver these therapeutic agents to the inner ear. Copyright (C) 1999 Elsevier Science Ireland Ltd.
KW - Cell culture
KW - Cochlea
KW - Hearing impairment
KW - Inner ear
KW - Ototoxicity
UR - http://www.scopus.com/inward/record.url?scp=0032751589&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032751589&partnerID=8YFLogxK
U2 - 10.1016/S0165-5876(99)00126-3
DO - 10.1016/S0165-5876(99)00126-3
M3 - Article
VL - 49
JO - International Journal of Pediatric Otorhinolaryngology
JF - International Journal of Pediatric Otorhinolaryngology
SN - 0165-5876
IS - SUPPL. 1
ER -