Growth factor therapy to the damaged inner ear: Clinical propects

Brigitte Malgrange, Jean Michel Rigo, Thomas R. Van De Water, Hinrich Staecker, Gustave Moonen, Philippe P. Lefebvre

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Most hearing loss results from lesions of the sensory cells and/or of the neurons of the auditory part of the inner ear. There is currently no treatment able to stop the progression of a hearing loss or to restore a lost auditory function. In this paper, we review the progress which has been made with respect to the regeneration and the protection of the hair cells and of the auditory neurons in the cochlea. In particular, we emphasize the control by growth factors of the protection/repair mechanisms of the neurosensory structures within the inner ear, in the prospect of the possible clinical use of these molecules. Finally, we discuss the different approaches which can be used to deliver these therapeutic agents to the inner ear. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)S19-S25
JournalInternational Journal of Pediatric Otorhinolaryngology
Issue numberSUPPL. 1
StatePublished - Oct 5 1999


  • Cell culture
  • Cochlea
  • Hearing impairment
  • Inner ear
  • Ototoxicity

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine
  • Surgery


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