Growth factor therapy to the damaged inner ear: Clinical propects

Brigitte Malgrange; Jean Michel Rigo; Thomas R. Van De Water; Hinrich Staecker; Gustave Moonen; Philippe P. Lefebvre

doi:10.1016/S0165-5876(99)00126-3

Growth factor therapy to the damaged inner ear: Clinical propects

Brigitte Malgrange, Jean Michel Rigo, Thomas R. Van De Water, Hinrich Staecker, Gustave Moonen, Philippe P. Lefebvre

Otolaryngology

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Most hearing loss results from lesions of the sensory cells and/or of the neurons of the auditory part of the inner ear. There is currently no treatment able to stop the progression of a hearing loss or to restore a lost auditory function. In this paper, we review the progress which has been made with respect to the regeneration and the protection of the hair cells and of the auditory neurons in the cochlea. In particular, we emphasize the control by growth factors of the protection/repair mechanisms of the neurosensory structures within the inner ear, in the prospect of the possible clinical use of these molecules. Finally, we discuss the different approaches which can be used to deliver these therapeutic agents to the inner ear. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	S19-S25
Journal	International Journal of Pediatric Otorhinolaryngology
Volume	49
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1016/S0165-5876(99)00126-3
State	Published - Oct 5 1999

Keywords

Cell culture
Cochlea
Hearing impairment
Inner ear
Ototoxicity

ASJC Scopus subject areas

Otorhinolaryngology
Pediatrics, Perinatology, and Child Health
Pulmonary and Respiratory Medicine
Surgery

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10.1016/S0165-5876(99)00126-3

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abstract = "Most hearing loss results from lesions of the sensory cells and/or of the neurons of the auditory part of the inner ear. There is currently no treatment able to stop the progression of a hearing loss or to restore a lost auditory function. In this paper, we review the progress which has been made with respect to the regeneration and the protection of the hair cells and of the auditory neurons in the cochlea. In particular, we emphasize the control by growth factors of the protection/repair mechanisms of the neurosensory structures within the inner ear, in the prospect of the possible clinical use of these molecules. Finally, we discuss the different approaches which can be used to deliver these therapeutic agents to the inner ear. Copyright (C) 1999 Elsevier Science Ireland Ltd.",

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AU - Staecker, Hinrich

AU - Moonen, Gustave

AU - Lefebvre, Philippe P.

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