Growth factor therapy to the damaged inner ear: Clinical propects

Brigitte Malgrange; Jean Michel Rigo; Thomas R. Van De Water; Hinrich Staecker; Gustave Moonen; Philippe P. Lefebvre

doi:10.1016/S0165-5876(99)00126-3

Growth factor therapy to the damaged inner ear: Clinical propects

Brigitte Malgrange, Jean Michel Rigo, Thomas R. Van De Water, Hinrich Staecker, Gustave Moonen, Philippe P. Lefebvre

Otolaryngology

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Most hearing loss results from lesions of the sensory cells and/or of the neurons of the auditory part of the inner ear. There is currently no treatment able to stop the progression of a hearing loss or to restore a lost auditory function. In this paper, we review the progress which has been made with respect to the regeneration and the protection of the hair cells and of the auditory neurons in the cochlea. In particular, we emphasize the control by growth factors of the protection/repair mechanisms of the neurosensory structures within the inner ear, in the prospect of the possible clinical use of these molecules. Finally, we discuss the different approaches which can be used to deliver these therapeutic agents to the inner ear. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	S19-S25
Journal	International Journal of Pediatric Otorhinolaryngology
Volume	49
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1016/S0165-5876(99)00126-3
State	Published - Oct 5 1999

Keywords

Cell culture
Cochlea
Hearing impairment
Inner ear
Ototoxicity

ASJC Scopus subject areas

Otorhinolaryngology
Pediatrics, Perinatology, and Child Health
Pulmonary and Respiratory Medicine
Surgery

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title = "Growth factor therapy to the damaged inner ear: Clinical propects",

abstract = "Most hearing loss results from lesions of the sensory cells and/or of the neurons of the auditory part of the inner ear. There is currently no treatment able to stop the progression of a hearing loss or to restore a lost auditory function. In this paper, we review the progress which has been made with respect to the regeneration and the protection of the hair cells and of the auditory neurons in the cochlea. In particular, we emphasize the control by growth factors of the protection/repair mechanisms of the neurosensory structures within the inner ear, in the prospect of the possible clinical use of these molecules. Finally, we discuss the different approaches which can be used to deliver these therapeutic agents to the inner ear. Copyright (C) 1999 Elsevier Science Ireland Ltd.",

keywords = "Cell culture, Cochlea, Hearing impairment, Inner ear, Ototoxicity",

author = "Brigitte Malgrange and Rigo, {Jean Michel} and {Van De Water}, {Thomas R.} and Hinrich Staecker and Gustave Moonen and Lefebvre, {Philippe P.}",

note = "Funding Information: This work was supported by the Fonds National de la Recherche Scientifique (FNRS), the Concerted Action of the French Community of Belgium, by the Fondation M{\'e}dicale Reine Elisabeth (FMRE) and the Shulsky Foundation. We thank P. Ernst, M. Wouters and A. Broze for their technical support and expertise. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

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doi = "10.1016/S0165-5876(99)00126-3",

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T2 - Clinical propects

AU - Malgrange, Brigitte

AU - Rigo, Jean Michel

AU - Van De Water, Thomas R.

AU - Staecker, Hinrich

AU - Moonen, Gustave

AU - Lefebvre, Philippe P.

N1 - Funding Information: This work was supported by the Fonds National de la Recherche Scientifique (FNRS), the Concerted Action of the French Community of Belgium, by the Fondation Médicale Reine Elisabeth (FMRE) and the Shulsky Foundation. We thank P. Ernst, M. Wouters and A. Broze for their technical support and expertise. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.

PY - 1999/10/5

Y1 - 1999/10/5

N2 - Most hearing loss results from lesions of the sensory cells and/or of the neurons of the auditory part of the inner ear. There is currently no treatment able to stop the progression of a hearing loss or to restore a lost auditory function. In this paper, we review the progress which has been made with respect to the regeneration and the protection of the hair cells and of the auditory neurons in the cochlea. In particular, we emphasize the control by growth factors of the protection/repair mechanisms of the neurosensory structures within the inner ear, in the prospect of the possible clinical use of these molecules. Finally, we discuss the different approaches which can be used to deliver these therapeutic agents to the inner ear. Copyright (C) 1999 Elsevier Science Ireland Ltd.

AB - Most hearing loss results from lesions of the sensory cells and/or of the neurons of the auditory part of the inner ear. There is currently no treatment able to stop the progression of a hearing loss or to restore a lost auditory function. In this paper, we review the progress which has been made with respect to the regeneration and the protection of the hair cells and of the auditory neurons in the cochlea. In particular, we emphasize the control by growth factors of the protection/repair mechanisms of the neurosensory structures within the inner ear, in the prospect of the possible clinical use of these molecules. Finally, we discuss the different approaches which can be used to deliver these therapeutic agents to the inner ear. Copyright (C) 1999 Elsevier Science Ireland Ltd.

KW - Cell culture

KW - Cochlea

KW - Hearing impairment

KW - Inner ear

KW - Ototoxicity

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ER -

Growth factor therapy to the damaged inner ear: Clinical propects

Abstract

Keywords

ASJC Scopus subject areas

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