Growth factor receptors, phospholipases, phospholipid kinases and actin reorganization

Sanford J. Gips, David E. Kandzari, Pascal Goldschmidt-Clermont

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Upon binding to their ligand, several growth factor receptors that contain a tyrosine kinase within their cytoplasmic domain [receptor tyrosine kinases (RTKs)] induce a substantial reorganization of the actin cytoskeleton. This change in actin superstructure is necessary to produce multiple motile responses within the target cells. RTKs catalyse the clustering of effector proteins within functional units underneath the plasma membrane. Upon reaching a critical mass, RTK-effector units send out signals through the metabolism of membrane phospholipids and other second messenger molecules that regulate the interaction of actin with its satellite regulatory molecules. Several actin binding proteins interact transiently with small clusters of membrane inositol phospholipids in vitro (4 to 5 phospholipid molecules per actin binding protein). Such transient complex formation can either down-regulate or up-regulate the interaction of regulatory proteins with actin. The phospholipids involved in the surface catalytic control of the actin cytoskeleton are metabolically very active and abundant in cells, and are therefore poised to mediate reactions linking signal transduction molecules to the reorganization of the actin cytoskeleton upon cell activation.

Original languageEnglish
Pages (from-to)201-208
Number of pages8
JournalSeminars in Cell and Developmental Biology
Volume5
Issue number3
StatePublished - Dec 1 1994
Externally publishedYes

Fingerprint

Growth Factor Receptors
Phospholipases
Actin Cytoskeleton
Actins
Microfilament Proteins
Phospholipids
Receptor Protein-Tyrosine Kinases
Protein-Tyrosine Kinases
Membranes
Second Messenger Systems
Cytoplasmic and Nuclear Receptors
Phosphatidylinositols
Cluster Analysis
Signal Transduction
Proteins
Up-Regulation
Down-Regulation
Cell Membrane
Ligands
actin kinase

Keywords

  • Actin
  • Actin binding proteins
  • Cell signaling
  • Phospholipase
  • Receptor tyrosine kinase

ASJC Scopus subject areas

  • Developmental Biology
  • Medicine(all)

Cite this

Growth factor receptors, phospholipases, phospholipid kinases and actin reorganization. / Gips, Sanford J.; Kandzari, David E.; Goldschmidt-Clermont, Pascal.

In: Seminars in Cell and Developmental Biology, Vol. 5, No. 3, 01.12.1994, p. 201-208.

Research output: Contribution to journalArticle

Gips, SJ, Kandzari, DE & Goldschmidt-Clermont, P 1994, 'Growth factor receptors, phospholipases, phospholipid kinases and actin reorganization', Seminars in Cell and Developmental Biology, vol. 5, no. 3, pp. 201-208.
Gips, Sanford J. ; Kandzari, David E. ; Goldschmidt-Clermont, Pascal. / Growth factor receptors, phospholipases, phospholipid kinases and actin reorganization. In: Seminars in Cell and Developmental Biology. 1994 ; Vol. 5, No. 3. pp. 201-208.
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