Growth factor mRNA expression in human head and neck malignant tumors

Giovana Thomas, E. E. Tubb, R. B. Sessions, K. J. Cullen

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objective: Growth factor overexpression has been shown to be an integral part of the growth promotion of a number of tumors, including breast carcinoma, colon carcinoma, and sarcomas. The role of peptide growth factors in the regulation of growth of head and neck cancers has not been extensively investigated, however. In this study, we present our preliminary results of the pattern of expression of four growth factors: insulinlike growth factor II, transforming growth factor-α, basic fibroblast growth factor, and platelet-derived growth factor A chain in human head and neck tumors. Design: We examined eight benign and 27 malignant human head and neck surgical specimens for the expression of growth factor messenger RNAs using the polymerase chain reaction technique. Results: Our preliminary data demonstrate that growth factor messenger RNA is expressed by most of our malignant head and neck cancer specimens and by all eight benign head and neck tissue specimens. However, we were not able to show any distinction in the pattern of growth factor RNA expression among the malignant head and neck surgical specimens for the four growth factors studied to date. Conclusions: These findings demonstrate that the expression of specific biologically active genes can be studied in routine surgical specimens using the polymerase chain reaction. The clinical prognostic significance of the overexpression of growth factors in head and neck malignancy as well as future therapeutic implications are discussed.

Original languageEnglish
Pages (from-to)1247-1252
Number of pages6
JournalArchives of Otolaryngology - Head and Neck Surgery
Volume119
Issue number11
StatePublished - Jan 1 1993
Externally publishedYes

Fingerprint

Intercellular Signaling Peptides and Proteins
Neck
Head
Messenger RNA
Neoplasms
Head and Neck Neoplasms
Polymerase Chain Reaction
Transforming Growth Factors
Fibroblast Growth Factor 2
DNA-Directed RNA Polymerases
Growth
Sarcoma
Colon
RNA
Breast Neoplasms
Carcinoma
Peptides
Genes

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Growth factor mRNA expression in human head and neck malignant tumors. / Thomas, Giovana; Tubb, E. E.; Sessions, R. B.; Cullen, K. J.

In: Archives of Otolaryngology - Head and Neck Surgery, Vol. 119, No. 11, 01.01.1993, p. 1247-1252.

Research output: Contribution to journalArticle

Thomas, Giovana ; Tubb, E. E. ; Sessions, R. B. ; Cullen, K. J. / Growth factor mRNA expression in human head and neck malignant tumors. In: Archives of Otolaryngology - Head and Neck Surgery. 1993 ; Vol. 119, No. 11. pp. 1247-1252.
@article{e038bc2af97b4d2db15b248f82ba2872,
title = "Growth factor mRNA expression in human head and neck malignant tumors",
abstract = "Objective: Growth factor overexpression has been shown to be an integral part of the growth promotion of a number of tumors, including breast carcinoma, colon carcinoma, and sarcomas. The role of peptide growth factors in the regulation of growth of head and neck cancers has not been extensively investigated, however. In this study, we present our preliminary results of the pattern of expression of four growth factors: insulinlike growth factor II, transforming growth factor-α, basic fibroblast growth factor, and platelet-derived growth factor A chain in human head and neck tumors. Design: We examined eight benign and 27 malignant human head and neck surgical specimens for the expression of growth factor messenger RNAs using the polymerase chain reaction technique. Results: Our preliminary data demonstrate that growth factor messenger RNA is expressed by most of our malignant head and neck cancer specimens and by all eight benign head and neck tissue specimens. However, we were not able to show any distinction in the pattern of growth factor RNA expression among the malignant head and neck surgical specimens for the four growth factors studied to date. Conclusions: These findings demonstrate that the expression of specific biologically active genes can be studied in routine surgical specimens using the polymerase chain reaction. The clinical prognostic significance of the overexpression of growth factors in head and neck malignancy as well as future therapeutic implications are discussed.",
author = "Giovana Thomas and Tubb, {E. E.} and Sessions, {R. B.} and Cullen, {K. J.}",
year = "1993",
month = "1",
day = "1",
language = "English",
volume = "119",
pages = "1247--1252",
journal = "JAMA Otolaryngology - Head and Neck Surgery",
issn = "2168-6181",
publisher = "American Medical Association",
number = "11",

}

TY - JOUR

T1 - Growth factor mRNA expression in human head and neck malignant tumors

AU - Thomas, Giovana

AU - Tubb, E. E.

AU - Sessions, R. B.

AU - Cullen, K. J.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Objective: Growth factor overexpression has been shown to be an integral part of the growth promotion of a number of tumors, including breast carcinoma, colon carcinoma, and sarcomas. The role of peptide growth factors in the regulation of growth of head and neck cancers has not been extensively investigated, however. In this study, we present our preliminary results of the pattern of expression of four growth factors: insulinlike growth factor II, transforming growth factor-α, basic fibroblast growth factor, and platelet-derived growth factor A chain in human head and neck tumors. Design: We examined eight benign and 27 malignant human head and neck surgical specimens for the expression of growth factor messenger RNAs using the polymerase chain reaction technique. Results: Our preliminary data demonstrate that growth factor messenger RNA is expressed by most of our malignant head and neck cancer specimens and by all eight benign head and neck tissue specimens. However, we were not able to show any distinction in the pattern of growth factor RNA expression among the malignant head and neck surgical specimens for the four growth factors studied to date. Conclusions: These findings demonstrate that the expression of specific biologically active genes can be studied in routine surgical specimens using the polymerase chain reaction. The clinical prognostic significance of the overexpression of growth factors in head and neck malignancy as well as future therapeutic implications are discussed.

AB - Objective: Growth factor overexpression has been shown to be an integral part of the growth promotion of a number of tumors, including breast carcinoma, colon carcinoma, and sarcomas. The role of peptide growth factors in the regulation of growth of head and neck cancers has not been extensively investigated, however. In this study, we present our preliminary results of the pattern of expression of four growth factors: insulinlike growth factor II, transforming growth factor-α, basic fibroblast growth factor, and platelet-derived growth factor A chain in human head and neck tumors. Design: We examined eight benign and 27 malignant human head and neck surgical specimens for the expression of growth factor messenger RNAs using the polymerase chain reaction technique. Results: Our preliminary data demonstrate that growth factor messenger RNA is expressed by most of our malignant head and neck cancer specimens and by all eight benign head and neck tissue specimens. However, we were not able to show any distinction in the pattern of growth factor RNA expression among the malignant head and neck surgical specimens for the four growth factors studied to date. Conclusions: These findings demonstrate that the expression of specific biologically active genes can be studied in routine surgical specimens using the polymerase chain reaction. The clinical prognostic significance of the overexpression of growth factors in head and neck malignancy as well as future therapeutic implications are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0027378491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027378491&partnerID=8YFLogxK

M3 - Article

C2 - 7692890

AN - SCOPUS:0027378491

VL - 119

SP - 1247

EP - 1252

JO - JAMA Otolaryngology - Head and Neck Surgery

JF - JAMA Otolaryngology - Head and Neck Surgery

SN - 2168-6181

IS - 11

ER -