Ground truth for evaluation of ischemic stroke hybrid segmentation in a rat model of temporary middle cerebral artery occlusion

C. Imielinska, J. Rosiene, Y. Jin, X. Liu, J. Udupa, B. Zacharia, R. Komotar, J. Mocco, M. Sughrue, B. Grobelny, A. Sisti, J. Silverberg, J. Khandji, H. Cohen, E. S. Connolly, A. D'Ambrosio

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

In vivo rodent models of focal cerebral ischemia have been developed to investigate stroke therapy. Typically these models require rapid quantification of cerebral infarct volumes using vital stains with tetrazolium salts to delineate the extent of neuronal death. To avoid animal sacrifice, we sought a study with MR acquired volumetric rat data where surrogate of ground truth is obtained by repeated manual delineation by experts, and an automated hybrid segmentation is evaluated for accuracy. We propose a rating system for the expert delineations that captures intra- and inter-expert discrepancy. Our preliminary results show that surrogate ground truth derived from MR data is at least as good as the one derived from histologic stained slices. Hence animal sacrifice is not necessary to evaluate ischemic stroke automated segmentation in a rat model of temporary middle cerebral artery occlusion.

Original languageEnglish (US)
Pages (from-to)74-79
Number of pages6
JournalInternational Congress Series
Volume1281
DOIs
StatePublished - May 1 2005
Externally publishedYes

Keywords

  • Evaluation
  • Ground truth
  • Magnetic resonance
  • Quality
  • Segmentation
  • Stroke

ASJC Scopus subject areas

  • Medicine(all)

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    Imielinska, C., Rosiene, J., Jin, Y., Liu, X., Udupa, J., Zacharia, B., Komotar, R., Mocco, J., Sughrue, M., Grobelny, B., Sisti, A., Silverberg, J., Khandji, J., Cohen, H., Connolly, E. S., & D'Ambrosio, A. (2005). Ground truth for evaluation of ischemic stroke hybrid segmentation in a rat model of temporary middle cerebral artery occlusion. International Congress Series, 1281, 74-79. https://doi.org/10.1016/j.ics.2005.03.336