Granulomatous slack skin-like clinical findings in Sézary syndrome

Begoña Echeverria, Magalys Vitiello, Clara Milikowski, Francisco Kerdel

Research output: Contribution to journalArticlepeer-review


Granulomatous slack skin (GSS) is a very rare condition that has been described as a variant of mycosis fungoides. It is characterized by the development of bulky and pendulous skin folds in flexural areas that are histologically formed by atypical T lymphocytes, histiocytes and giant cells. We report the case of a 37-year-old African-American female with history of Sézary syndrome (SS) that while on treatment for the disease and in a space of 1 month developed exorbitant slack folds in the axillae and cervical area mimicking GSS. The absence of giant cells and epithelioid granulomas in the biopsy ruled out this diagnosis. We report this peculiar SS presentation that clinically resembles GSS, but with histopathology that does not show the typical features of this condition. We also review the literature in regard to SS, GSS and granulomatous mycosis fungoides (GMF), particularly the existing criteria to differentiate these various entities.

Original languageEnglish (US)
Pages (from-to)992-995
Number of pages4
JournalJournal of Cutaneous Pathology
Issue number12
StatePublished - Dec 1 2015


  • Sézary syndrome
  • cutaneous T cell lymphoma
  • mycosis fungoides

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology


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