TY - JOUR
T1 - Graft-versus-host disease after allogeneic stem cell transplantation
T2 - Evolving concepts and novel therapies including photopheresis
AU - Komanduri, Krishna V.
AU - Couriel, Daniel
AU - Champlin, Richard E.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2006/1
Y1 - 2006/1
N2 - Graft-versus-host disease (GVHD) remains a source of significant morbidity and mortality in the setting of allogeneic stem cell transplantation. Improving outcomes in stem cell transplant recipients will require additional therapeutic modalities for GVHD, especially for those patients who fail to respond to initial therapy with steroids. This article provides an introduction to accompanying articles in this issue of Biology of Blood and Marrow Transplantation concerning the current state of GVHD management with an emphasis on the role of extracorporeal photopheresis as a therapeutic modality. Topics discussed include challenges associated with the design of clinical studies of GVHD therapies, the efficacy of and proposed mechanisms of photopheresis in the setting of GVHD, and our emerging understanding of regulatory T cell biology as it relates to allogeneic stem cell transplantation.
AB - Graft-versus-host disease (GVHD) remains a source of significant morbidity and mortality in the setting of allogeneic stem cell transplantation. Improving outcomes in stem cell transplant recipients will require additional therapeutic modalities for GVHD, especially for those patients who fail to respond to initial therapy with steroids. This article provides an introduction to accompanying articles in this issue of Biology of Blood and Marrow Transplantation concerning the current state of GVHD management with an emphasis on the role of extracorporeal photopheresis as a therapeutic modality. Topics discussed include challenges associated with the design of clinical studies of GVHD therapies, the efficacy of and proposed mechanisms of photopheresis in the setting of GVHD, and our emerging understanding of regulatory T cell biology as it relates to allogeneic stem cell transplantation.
KW - Alloreactivity
KW - Graft-versus-host disease
KW - Photopheresis
KW - Regulatory T cells
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U2 - 10.1016/j.bbmt.2005.11.003
DO - 10.1016/j.bbmt.2005.11.003
M3 - Article
C2 - 16399595
AN - SCOPUS:29844452471
VL - 12
SP - 1
EP - 6
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
SN - 1083-8791
IS - 1 SUPPL. 2
ER -