Graft failure due to noncompliance among 628 kidney transplant recipients with long-term follow-up

A single-center observational study

Jeffrey J. Gaynor, Gaetano Ciancio, Giselle Guerra, Junichiro Sageshima, Lois Hanson, David Roth, Linda Chen, Warren Kupin, Adela Mattiazzi, Lissett Tueros, Sandra Flores, Jason Aminsharifi, Shivam Joshi, Zoila Chediak, Phillip Ruiz, Rodrigo Vianna, George W. Burke

Research output: Contribution to journalArticle

Abstract

BACKGROUND: In adult kidney transplantation, there is no clear consensus on the incidence of graft failure-due-to noncompliance (GFNC), with some reporting it as relatively uncommon and others as a major cause of late graft failure. We suspected that GFNC was a major cause of late graft loss at our center but did not know the extent of this problem. METHODS: In our prospectively followed cohort of 628 adult, primary kidney-alone transplant recipients with long-term follow-up, GFNC and other graft loss causes were determined from our ongoing clinical evaluations. Using competing risks methodology, we determined the overall percentage of patients developing GFNC and the significant prognostic factors for its hazard rate and cumulative incidence (via Cox regression). RESULTS: Cumulative incidence estimates (±standard error) of GFNC (n=29), GF-with-compliance (n=46), receiving a never-functioning graft (n=7), and death-with-a-functioning-graft (n=53) at 101 months after transplant (last-observed-graft loss) were as follows: 9.8%±2.4%, 10.9%±1.7%, 1.1%±0.4%, and 13.0%±1.9%, respectively. Only three patients experienced GFNC during the first 24 months; GFNC represented 48.1% (26/54) of death-censored GFs beyond 24 months. Two baseline variables were jointly associated with a significantly higher GFNC hazard and cumulative incidence: younger recipient age (P<0.000001 each) and non-white recipient (P=0.004 and P=0.02). Estimated percentages of ever developing GFNC were 28.4%±6.5% among 79 non-whites younger than 35 years versus 0.0% (0/144) among whites 50 years or older. Among 302 recipients younger than 50 years, 18.1%±4.1% developed GFNC, representing 67.6% (25/37) of its death-censored graft failures observed beyond 24 months after transplant. CONCLUSIONS: GFNC is a major cause of late GF at our center, with younger and non-white recipients at a significantly greater GFNC risk. Interventional approaches to eliminate GFNC could dramatically improve long-term kidney graft survival.

Original languageEnglish
JournalTransplantation
DOIs
StateAccepted/In press - Jan 17 2014

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Observational Studies
Transplants
Kidney
Transplant Recipients
Incidence
Graft Survival

ASJC Scopus subject areas

  • Transplantation

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Graft failure due to noncompliance among 628 kidney transplant recipients with long-term follow-up : A single-center observational study. / Gaynor, Jeffrey J.; Ciancio, Gaetano; Guerra, Giselle; Sageshima, Junichiro; Hanson, Lois; Roth, David; Chen, Linda; Kupin, Warren; Mattiazzi, Adela; Tueros, Lissett; Flores, Sandra; Aminsharifi, Jason; Joshi, Shivam; Chediak, Zoila; Ruiz, Phillip; Vianna, Rodrigo; Burke, George W.

In: Transplantation, 17.01.2014.

Research output: Contribution to journalArticle

Gaynor, JJ, Ciancio, G, Guerra, G, Sageshima, J, Hanson, L, Roth, D, Chen, L, Kupin, W, Mattiazzi, A, Tueros, L, Flores, S, Aminsharifi, J, Joshi, S, Chediak, Z, Ruiz, P, Vianna, R & Burke, GW 2014, 'Graft failure due to noncompliance among 628 kidney transplant recipients with long-term follow-up: A single-center observational study', Transplantation. https://doi.org/10.1097/01.TP.0000438199.76531.4a
Gaynor, Jeffrey J. ; Ciancio, Gaetano ; Guerra, Giselle ; Sageshima, Junichiro ; Hanson, Lois ; Roth, David ; Chen, Linda ; Kupin, Warren ; Mattiazzi, Adela ; Tueros, Lissett ; Flores, Sandra ; Aminsharifi, Jason ; Joshi, Shivam ; Chediak, Zoila ; Ruiz, Phillip ; Vianna, Rodrigo ; Burke, George W. / Graft failure due to noncompliance among 628 kidney transplant recipients with long-term follow-up : A single-center observational study. In: Transplantation. 2014.
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abstract = "BACKGROUND: In adult kidney transplantation, there is no clear consensus on the incidence of graft failure-due-to noncompliance (GFNC), with some reporting it as relatively uncommon and others as a major cause of late graft failure. We suspected that GFNC was a major cause of late graft loss at our center but did not know the extent of this problem. METHODS: In our prospectively followed cohort of 628 adult, primary kidney-alone transplant recipients with long-term follow-up, GFNC and other graft loss causes were determined from our ongoing clinical evaluations. Using competing risks methodology, we determined the overall percentage of patients developing GFNC and the significant prognostic factors for its hazard rate and cumulative incidence (via Cox regression). RESULTS: Cumulative incidence estimates (±standard error) of GFNC (n=29), GF-with-compliance (n=46), receiving a never-functioning graft (n=7), and death-with-a-functioning-graft (n=53) at 101 months after transplant (last-observed-graft loss) were as follows: 9.8{\%}±2.4{\%}, 10.9{\%}±1.7{\%}, 1.1{\%}±0.4{\%}, and 13.0{\%}±1.9{\%}, respectively. Only three patients experienced GFNC during the first 24 months; GFNC represented 48.1{\%} (26/54) of death-censored GFs beyond 24 months. Two baseline variables were jointly associated with a significantly higher GFNC hazard and cumulative incidence: younger recipient age (P<0.000001 each) and non-white recipient (P=0.004 and P=0.02). Estimated percentages of ever developing GFNC were 28.4{\%}±6.5{\%} among 79 non-whites younger than 35 years versus 0.0{\%} (0/144) among whites 50 years or older. Among 302 recipients younger than 50 years, 18.1{\%}±4.1{\%} developed GFNC, representing 67.6{\%} (25/37) of its death-censored graft failures observed beyond 24 months after transplant. CONCLUSIONS: GFNC is a major cause of late GF at our center, with younger and non-white recipients at a significantly greater GFNC risk. Interventional approaches to eliminate GFNC could dramatically improve long-term kidney graft survival.",
author = "Gaynor, {Jeffrey J.} and Gaetano Ciancio and Giselle Guerra and Junichiro Sageshima and Lois Hanson and David Roth and Linda Chen and Warren Kupin and Adela Mattiazzi and Lissett Tueros and Sandra Flores and Jason Aminsharifi and Shivam Joshi and Zoila Chediak and Phillip Ruiz and Rodrigo Vianna and Burke, {George W.}",
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T1 - Graft failure due to noncompliance among 628 kidney transplant recipients with long-term follow-up

T2 - A single-center observational study

AU - Gaynor, Jeffrey J.

AU - Ciancio, Gaetano

AU - Guerra, Giselle

AU - Sageshima, Junichiro

AU - Hanson, Lois

AU - Roth, David

AU - Chen, Linda

AU - Kupin, Warren

AU - Mattiazzi, Adela

AU - Tueros, Lissett

AU - Flores, Sandra

AU - Aminsharifi, Jason

AU - Joshi, Shivam

AU - Chediak, Zoila

AU - Ruiz, Phillip

AU - Vianna, Rodrigo

AU - Burke, George W.

PY - 2014/1/17

Y1 - 2014/1/17

N2 - BACKGROUND: In adult kidney transplantation, there is no clear consensus on the incidence of graft failure-due-to noncompliance (GFNC), with some reporting it as relatively uncommon and others as a major cause of late graft failure. We suspected that GFNC was a major cause of late graft loss at our center but did not know the extent of this problem. METHODS: In our prospectively followed cohort of 628 adult, primary kidney-alone transplant recipients with long-term follow-up, GFNC and other graft loss causes were determined from our ongoing clinical evaluations. Using competing risks methodology, we determined the overall percentage of patients developing GFNC and the significant prognostic factors for its hazard rate and cumulative incidence (via Cox regression). RESULTS: Cumulative incidence estimates (±standard error) of GFNC (n=29), GF-with-compliance (n=46), receiving a never-functioning graft (n=7), and death-with-a-functioning-graft (n=53) at 101 months after transplant (last-observed-graft loss) were as follows: 9.8%±2.4%, 10.9%±1.7%, 1.1%±0.4%, and 13.0%±1.9%, respectively. Only three patients experienced GFNC during the first 24 months; GFNC represented 48.1% (26/54) of death-censored GFs beyond 24 months. Two baseline variables were jointly associated with a significantly higher GFNC hazard and cumulative incidence: younger recipient age (P<0.000001 each) and non-white recipient (P=0.004 and P=0.02). Estimated percentages of ever developing GFNC were 28.4%±6.5% among 79 non-whites younger than 35 years versus 0.0% (0/144) among whites 50 years or older. Among 302 recipients younger than 50 years, 18.1%±4.1% developed GFNC, representing 67.6% (25/37) of its death-censored graft failures observed beyond 24 months after transplant. CONCLUSIONS: GFNC is a major cause of late GF at our center, with younger and non-white recipients at a significantly greater GFNC risk. Interventional approaches to eliminate GFNC could dramatically improve long-term kidney graft survival.

AB - BACKGROUND: In adult kidney transplantation, there is no clear consensus on the incidence of graft failure-due-to noncompliance (GFNC), with some reporting it as relatively uncommon and others as a major cause of late graft failure. We suspected that GFNC was a major cause of late graft loss at our center but did not know the extent of this problem. METHODS: In our prospectively followed cohort of 628 adult, primary kidney-alone transplant recipients with long-term follow-up, GFNC and other graft loss causes were determined from our ongoing clinical evaluations. Using competing risks methodology, we determined the overall percentage of patients developing GFNC and the significant prognostic factors for its hazard rate and cumulative incidence (via Cox regression). RESULTS: Cumulative incidence estimates (±standard error) of GFNC (n=29), GF-with-compliance (n=46), receiving a never-functioning graft (n=7), and death-with-a-functioning-graft (n=53) at 101 months after transplant (last-observed-graft loss) were as follows: 9.8%±2.4%, 10.9%±1.7%, 1.1%±0.4%, and 13.0%±1.9%, respectively. Only three patients experienced GFNC during the first 24 months; GFNC represented 48.1% (26/54) of death-censored GFs beyond 24 months. Two baseline variables were jointly associated with a significantly higher GFNC hazard and cumulative incidence: younger recipient age (P<0.000001 each) and non-white recipient (P=0.004 and P=0.02). Estimated percentages of ever developing GFNC were 28.4%±6.5% among 79 non-whites younger than 35 years versus 0.0% (0/144) among whites 50 years or older. Among 302 recipients younger than 50 years, 18.1%±4.1% developed GFNC, representing 67.6% (25/37) of its death-censored graft failures observed beyond 24 months after transplant. CONCLUSIONS: GFNC is a major cause of late GF at our center, with younger and non-white recipients at a significantly greater GFNC risk. Interventional approaches to eliminate GFNC could dramatically improve long-term kidney graft survival.

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