Grading of spindle cell sarcomas in fine-needle aspiration biopsy specimens

Michele M. Weir, Andrew Rosenberg, Debra A. Bell

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We studied whether histologic criteria for grading sarcomas could be applied to fine-needle aspiration biopsy (FNAB) specimens of adult spindle cell sarcomas, without knowledge of the sarcoma subtype, by reviewing 36 specimens. Grade I was assigned for minimal nuclear atypia and overlap, no necrosis, and rare mitotic figures, and grade 2 for moderate nuclear atypia, at least moderate nuclear overlap, appreciable mitotic figures, and necrosis. Severe nuclear atypia distinguished grade 3 from grade 2. A major noncorrelation between FNAB and histologic grades was defined as a misclassification of grade 1 vs grade 2 or 3. FNAB grades assigned were grade 1, 1; grade 2, 25; and grade 3, 10. There was 1 major noncorrelation due to a probable FNAB interpretation error. In 15 of 16 FNAB specimens of grade 2 or 3 sarcomas lacking mitotic figures, necrosis, or both, the nuclear atypia reflected the grade. In the remaining case, the degree of nuclear overlap and necrosis determined the grade. The histologic grading of sarcomas can be applied accurately to most FNAB specimens of spindle cell sarcomas without knowledge of the sarcoma subtype.

Original languageEnglish
Pages (from-to)784-790
Number of pages7
JournalAmerican Journal of Clinical Pathology
Volume112
Issue number6
StatePublished - Dec 1 1999
Externally publishedYes

Fingerprint

Fine Needle Biopsy
Sarcoma
Necrosis

Keywords

  • Aspiration biopsy
  • Grading
  • Spindle cell sarcomas

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Grading of spindle cell sarcomas in fine-needle aspiration biopsy specimens. / Weir, Michele M.; Rosenberg, Andrew; Bell, Debra A.

In: American Journal of Clinical Pathology, Vol. 112, No. 6, 01.12.1999, p. 784-790.

Research output: Contribution to journalArticle

@article{142e9b80763c4a59b565b7c614f19e5d,
title = "Grading of spindle cell sarcomas in fine-needle aspiration biopsy specimens",
abstract = "We studied whether histologic criteria for grading sarcomas could be applied to fine-needle aspiration biopsy (FNAB) specimens of adult spindle cell sarcomas, without knowledge of the sarcoma subtype, by reviewing 36 specimens. Grade I was assigned for minimal nuclear atypia and overlap, no necrosis, and rare mitotic figures, and grade 2 for moderate nuclear atypia, at least moderate nuclear overlap, appreciable mitotic figures, and necrosis. Severe nuclear atypia distinguished grade 3 from grade 2. A major noncorrelation between FNAB and histologic grades was defined as a misclassification of grade 1 vs grade 2 or 3. FNAB grades assigned were grade 1, 1; grade 2, 25; and grade 3, 10. There was 1 major noncorrelation due to a probable FNAB interpretation error. In 15 of 16 FNAB specimens of grade 2 or 3 sarcomas lacking mitotic figures, necrosis, or both, the nuclear atypia reflected the grade. In the remaining case, the degree of nuclear overlap and necrosis determined the grade. The histologic grading of sarcomas can be applied accurately to most FNAB specimens of spindle cell sarcomas without knowledge of the sarcoma subtype.",
keywords = "Aspiration biopsy, Grading, Spindle cell sarcomas",
author = "Weir, {Michele M.} and Andrew Rosenberg and Bell, {Debra A.}",
year = "1999",
month = "12",
day = "1",
language = "English",
volume = "112",
pages = "784--790",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "6",

}

TY - JOUR

T1 - Grading of spindle cell sarcomas in fine-needle aspiration biopsy specimens

AU - Weir, Michele M.

AU - Rosenberg, Andrew

AU - Bell, Debra A.

PY - 1999/12/1

Y1 - 1999/12/1

N2 - We studied whether histologic criteria for grading sarcomas could be applied to fine-needle aspiration biopsy (FNAB) specimens of adult spindle cell sarcomas, without knowledge of the sarcoma subtype, by reviewing 36 specimens. Grade I was assigned for minimal nuclear atypia and overlap, no necrosis, and rare mitotic figures, and grade 2 for moderate nuclear atypia, at least moderate nuclear overlap, appreciable mitotic figures, and necrosis. Severe nuclear atypia distinguished grade 3 from grade 2. A major noncorrelation between FNAB and histologic grades was defined as a misclassification of grade 1 vs grade 2 or 3. FNAB grades assigned were grade 1, 1; grade 2, 25; and grade 3, 10. There was 1 major noncorrelation due to a probable FNAB interpretation error. In 15 of 16 FNAB specimens of grade 2 or 3 sarcomas lacking mitotic figures, necrosis, or both, the nuclear atypia reflected the grade. In the remaining case, the degree of nuclear overlap and necrosis determined the grade. The histologic grading of sarcomas can be applied accurately to most FNAB specimens of spindle cell sarcomas without knowledge of the sarcoma subtype.

AB - We studied whether histologic criteria for grading sarcomas could be applied to fine-needle aspiration biopsy (FNAB) specimens of adult spindle cell sarcomas, without knowledge of the sarcoma subtype, by reviewing 36 specimens. Grade I was assigned for minimal nuclear atypia and overlap, no necrosis, and rare mitotic figures, and grade 2 for moderate nuclear atypia, at least moderate nuclear overlap, appreciable mitotic figures, and necrosis. Severe nuclear atypia distinguished grade 3 from grade 2. A major noncorrelation between FNAB and histologic grades was defined as a misclassification of grade 1 vs grade 2 or 3. FNAB grades assigned were grade 1, 1; grade 2, 25; and grade 3, 10. There was 1 major noncorrelation due to a probable FNAB interpretation error. In 15 of 16 FNAB specimens of grade 2 or 3 sarcomas lacking mitotic figures, necrosis, or both, the nuclear atypia reflected the grade. In the remaining case, the degree of nuclear overlap and necrosis determined the grade. The histologic grading of sarcomas can be applied accurately to most FNAB specimens of spindle cell sarcomas without knowledge of the sarcoma subtype.

KW - Aspiration biopsy

KW - Grading

KW - Spindle cell sarcomas

UR - http://www.scopus.com/inward/record.url?scp=0033491388&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033491388&partnerID=8YFLogxK

M3 - Article

C2 - 10587701

AN - SCOPUS:0033491388

VL - 112

SP - 784

EP - 790

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

SN - 0002-9173

IS - 6

ER -