Good stress, bad stress and oxidative stress: Insights from anticipatory cortisol reactivity

Kirstin Aschbacher, Aoife O'Donovan, Owen M. Wolkowitz, Firdaus Dhabhar, Yali Su, Elissa Epel

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

Chronic psychological stress appears to accelerate biological aging, and oxidative damage is an important potential mediator of this process. However, the mechanisms by which psychological stress promotes oxidative damage are poorly understood. This study investigates the theory that cortisol increases in response to an acutely stressful event have the potential to either enhance or undermine psychobiological resilience to oxidative damage, depending on the body's prior exposure to chronic psychological stress. In order to achieve a range of chronic stress exposure, forty-eight post-menopausal women were recruited in a case-control design that matched women caring for spouses with dementia (a chronic stress model) with similarly aged control women whose spouses were healthy. Participants completed a questionnaire assessing perceived stress over the previous month and provided fasting blood. Three markers of oxidative damage were assessed: 8-iso-prostaglandin F (IsoP), lipid peroxidation, 8-hydroxyguanosine (8-oxoG) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), reflecting oxidative damage to RNA/DNA respectively. Within approximately one week, participants completed a standardized acute laboratory stress task while salivary cortisol responses were measured. The increase from 0 to 30min was defined as "peak" cortisol reactivity, while the increase from 0 to 15min was defined as "anticipatory" cortisol reactivity, representing a cortisol response that began while preparing for the stress task. Women under chronic stress had higher 8-oxoG, oxidative damage to RNA (p < .01). A moderated mediation model was tested, in which it was hypothesized that heightened anticipatory cortisol reactivity would mediate the relationship between perceived stress and elevated oxidative stress damage, but only among women under chronic stress. Consistent with this model, bootstrapped path analysis found significant indirect paths from perceived stress to 8-oxoG and IsoP (but not 8-OHdG) via anticipatory cortisol reactivity, showing the expected relations among chronically stressed participants (p≤.01) Intriguingly, among those with low chronic stress exposure, moderate (compared to low) levels of perceived stress were associated with reduced levels of oxidative damage. Hence, this study supports the emerging model that chronic stress exposure promotes oxidative damage through frequent and sustained activation of the hypothalamic-pituitary-adrenal axis. It also supports the less studied model of 'eustress' - that manageable levels of life stress may enhance psychobiological resilience to oxidative damage.

Original languageEnglish (US)
Pages (from-to)1698-1708
Number of pages11
JournalPsychoneuroendocrinology
Volume38
Issue number9
DOIs
StatePublished - Sep 1 2013
Externally publishedYes

Fingerprint

Hydrocortisone
Oxidative Stress
Psychological Stress
Dinoprost
Spouses
RNA
Lipid Peroxidation
Dementia
Fasting
DNA

Keywords

  • Acute stress
  • Biological aging
  • Chronic stress
  • Cortisol
  • DNA/RNA damage
  • Eustress
  • Hypothalamic-pituitary-adrenal axis
  • Oxidative stress
  • Reactive oxygen species
  • Resilience

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Good stress, bad stress and oxidative stress : Insights from anticipatory cortisol reactivity. / Aschbacher, Kirstin; O'Donovan, Aoife; Wolkowitz, Owen M.; Dhabhar, Firdaus; Su, Yali; Epel, Elissa.

In: Psychoneuroendocrinology, Vol. 38, No. 9, 01.09.2013, p. 1698-1708.

Research output: Contribution to journalArticle

Aschbacher, Kirstin ; O'Donovan, Aoife ; Wolkowitz, Owen M. ; Dhabhar, Firdaus ; Su, Yali ; Epel, Elissa. / Good stress, bad stress and oxidative stress : Insights from anticipatory cortisol reactivity. In: Psychoneuroendocrinology. 2013 ; Vol. 38, No. 9. pp. 1698-1708.
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