Gonadotropin-secreting pituitary adenoma with concomitant hypersecretion of testosterone and elevated sperm count. Treatment with LRH agonist

A. Zarate, M. E. Fonseca, M. Mason, R. Tapia, R. Miranda, K. Kovacs, Andrew V Schally

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Hypersecretion of both FSH and LH was demonstrated in a man with pituitary macroadenoma, who also presented elevated levels of blood testosterone and an increased sperm count. The patient underwent transsphenoidal surgery followed immediately by cranial irradiation. Immunocytochemical analysis of the tumour revealed the presence of FSH, LH, TSH and the α-subunit. Gel chromatography of the serum on Sephadex G-100 revealed immunoactive FSH, LH and the α-subunit which coeluted with the labelled standards of corresponding hormones. Blood levels of both gonadotropins and testosterone remained persistently elevatd up to one year following surgical decompression of the tumour and radiotherapy. It was decided to treat this patient with sc administration of 100 μg D-Trp6-LRH biweekly. After 20 weeks, LRH-analogue treatment resulted in the reduction of serum FSH and LH levels and a diminishing in tumour size as assessed by computed tomography scan of the pituitary. This report shows that in a patient with clinically and biochemically documented gonadotropin-secreting adenoma, inducing a state of persistent gonadal hyperfunction, pituitary surgery and cranial irradiation failed to normalize the biochemical abnormality; however, therapy with D-Trp6-LRH agonist induced clinical, biochemical and radiologic improvement.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalActa Endocrinologica
Volume113
Issue number1
StatePublished - Nov 26 1986
Externally publishedYes

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Sperm Count
Pituitary Neoplasms
Gonadotropins
Cranial Irradiation
Testosterone
Pituitary Irradiation
Surgical Decompression
Neoplasms
Serum
Adenoma
Gel Chromatography
Radiotherapy
Therapeutics
Tomography
Hormones

ASJC Scopus subject areas

  • Endocrinology

Cite this

Gonadotropin-secreting pituitary adenoma with concomitant hypersecretion of testosterone and elevated sperm count. Treatment with LRH agonist. / Zarate, A.; Fonseca, M. E.; Mason, M.; Tapia, R.; Miranda, R.; Kovacs, K.; Schally, Andrew V.

In: Acta Endocrinologica, Vol. 113, No. 1, 26.11.1986, p. 29-34.

Research output: Contribution to journalArticle

Zarate, A. ; Fonseca, M. E. ; Mason, M. ; Tapia, R. ; Miranda, R. ; Kovacs, K. ; Schally, Andrew V. / Gonadotropin-secreting pituitary adenoma with concomitant hypersecretion of testosterone and elevated sperm count. Treatment with LRH agonist. In: Acta Endocrinologica. 1986 ; Vol. 113, No. 1. pp. 29-34.
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