Gonadotropin-releasing hormone: One polypeptide regulates secretion of luteinizing and follicle-stimulating hormones

A. V. Schally, A. Arimura, A. J. Kastin, H. Matsuo, Y. Baba, T. W. Redding, R. M.G. Nair, L. Debeljuk, W. F. White

Research output: Contribution to journalArticlepeer-review

532 Scopus citations

Abstract

A polypeptide isolated from porcine hypothalami stimulates the release of both luteinizing hormone and follicle-stimulating hormone from the pituitaries of several species. This polypeptide has been structurally identified as (pyro)Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 and synthesized. The natural and synthetic materials share biological properties. It appears that this peptide represents the hypothalamic hormone regulating the secretion of both luteinizing hormone and follicle-stimulating hormone.

Original languageEnglish (US)
Pages (from-to)1036-1038
Number of pages3
JournalScience
Volume173
Issue number4001
DOIs
StatePublished - 1971
Externally publishedYes

ASJC Scopus subject areas

  • General

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