Gonadotropin releasing hormone (GnRH): Neuropharmacological studies

Nicholas P. Plotnikoff, Wilfred F. White, Abba J. Kastin, Andrew V. Schally

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The hypothalamic hormone GnRH was found to potentiate behavioral effects of DOPA and serotonin. In addition, GnRH was observed to reduce slightly audiogenic seizures as well as spontaneous motor activity. No significant effects were observed against footshock induced fighting or oxotremorine effects. These studies support our concept of the actions of hypothalamic peptides on the central nervous system.

Original languageEnglish (US)
Pages (from-to)1685-1691
Number of pages7
JournalLife Sciences
Issue number11
StatePublished - Dec 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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