The gonadotropin releasing activities of two synthetic analogs of luteinizing hormone releasing hormone (LH RH), D Ala 6 des Gly 10 LH RH ethylamide and D Leu 6 des Gly 10 LH RH ethylamide were evaluated in immature female rats after subcutaneous, intravaginal, and oral administration. Maximal peaks of serum LH and follicle stimulating hormone (FSH) levels after administration of both analogs by any of the three routes were obtained at 2 hours. Therefore, serum gonadotropin levels declined slowly, so that at 6 hours LH levels had returned to base line value, whereas FSH levels remained elevated for up to 10 hours. The integrated serum gonadotropin levels after LH RH and both analogs over a 10 hour period indicated that D Leu 6 des Gly 10 LH RH EA and D Ala 6 des Gly 10 LH RH EA and D Ala 6 des Gly 10 LH RH EA released more LH and FSH than did the LH RH decapeptide. The intense and long acting properties of these analogs in releasing LH and FSH suggest the possibility that they may be more useful therapeutically than LH RH.
|Original language||English (US)|
|Number of pages||7|
|State||Published - Jan 1 1975|
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology