Gonadotropin release during repeated administration of d-Leu 6 des Gly 10-LH-RH-EA at different stages of the menstrual cycle and in functional amenorrhea

J. P. Hanker, J. Knippenberg, A. J. Kastin, E. J. Wickings, Andrew V Schally, D. H. Coy, H. P. Schneider

Research output: Contribution to journalArticle

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Abstract

A highly potent analogue of LH-RH, d-Leu 6 des Gly 10 LH-RH-ethylamide was, used to study gonadotropin release after three repeated injections of a 25μg dose at 3-hourly intervals. Nine volunteers at different stages of the menstrual cycle and 14 patients with functional hypothalamic amenorrhea were investigated. LH secretion varied according to the functional state of the gonadostats, whereas FSH release did not show such differences. After repeated stimulation with the analogue, a tendency for diminished release of both gonadotropins was observed. Significant incremental changes of estradiol-17β levels occurred only after a decrease of pituitary responsiveness to further d-Leu 6 des Gly 10 LH-RH-EA stimuli was already evident. Therefore, it appears unlikely that estradiol-17β itself exerted a substantial negative feedback action on LH and FSH release in the authors experimental model. It is suggested that repeated administration of d-Leu 6 des Gly 10 LH-RH-EA leads to changes of pituitary receptor sensitivity.

Original languageEnglish
Pages (from-to)7-17
Number of pages11
JournalInternational Journal of Fertility
Volume25
Issue number1
StatePublished - Jul 4 1980
Externally publishedYes

Fingerprint

Amenorrhea
Menstrual Cycle
Gonadotropins
Gonadotropin-Releasing Hormone
Estradiol
Volunteers
Theoretical Models
Injections
decaglycine

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Gonadotropin release during repeated administration of d-Leu 6 des Gly 10-LH-RH-EA at different stages of the menstrual cycle and in functional amenorrhea. / Hanker, J. P.; Knippenberg, J.; Kastin, A. J.; Wickings, E. J.; Schally, Andrew V; Coy, D. H.; Schneider, H. P.

In: International Journal of Fertility, Vol. 25, No. 1, 04.07.1980, p. 7-17.

Research output: Contribution to journalArticle

Hanker, J. P. ; Knippenberg, J. ; Kastin, A. J. ; Wickings, E. J. ; Schally, Andrew V ; Coy, D. H. ; Schneider, H. P. / Gonadotropin release during repeated administration of d-Leu 6 des Gly 10-LH-RH-EA at different stages of the menstrual cycle and in functional amenorrhea. In: International Journal of Fertility. 1980 ; Vol. 25, No. 1. pp. 7-17.
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