Gonadotropin and prolactin secretion in human pseudocyesis: Effect of synthetic luteinizing hormone releasing hormone (LH RH) and thyrotropin releasing hormone (TRH)

A. Zarate, E. S. Canales, J. Soria, L. S. Jacobs, W. H. Daughaday, A. J. Kastin, A. V. Schally

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

In 2 patients with pseudocyesis a low concentration of serum gonadotropins as well as a high prolactin level was demonstrated. The intravenous administration of synthetic LH RH released significantly more LH in patients with pseudocyesis than in normal women. In contrast LH RH released comparable amounts of FSH in both groups of patients. The administration of TRH caused a greater increase in serum prolactin in both patients than has been observed in normal females. On the other hand, TRH elicited a normal rise in TSH in both patients. Corpora lutea were not observed during exploratory laparoscopy. On the basis of this study it is suggested that psychological factors acting through the hypothalamus cause excessive secretion of prolactin and decreased secretion of gonadotropins which in turn could precipitate pseudocyesis. The pituitary also maintains its capacity to respond to stimulation by exogenous hypothalamic hormones.

Original languageEnglish (US)
Pages (from-to)445-450
Number of pages6
JournalAnnales d'Endocrinologie
Volume35
Issue number4
StatePublished - Dec 1 1974
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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